Metabolomics in Applied Markets Research
Metabolomics Strengthens
Product Claims
Metabolomics is essential to investigating the roles of exercise, diet, environmental exposure, and aging as they relate to health and disease. By illuminating the complex associations between metabolites, metabolomic pathways, the microbiome, and wellness, metabolomics is intimately suited to elucidate the underlying biology of related diseases and guide the advancement and the development of successful disease prevention or mitigation strategies.
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Metabolomics Delivers Actionable Insights
Across Diverse Applied Markets
The Applied Markets sector spans a wide range of industries such as human nutrition, pet food/health, animal husbandry, agribiotech, consumer goods, and food/beverages. Regardless of the application, metabolomics is ideally suited to substantiate product claims by providing scientific data that is adjacent and relevant to the phenotype.
Animal Health and Nutrition
Unleash the Power of Metabolomics in Pet Care Research
Metabolomics is uniquely suited to decode the complex relationship between nutrition and metabolism, and to investigate the role that dietary components play in health, health maintenance, and disease. In animal health and veterinary science and medicine, metabolomics is being harnessed and applied to basic research, the discovery of biomarkers for treatment efficacy, and target discovery and validation. A metabolomics data stream provides pivotal scientific backing to support product/marketing claims.
Skin Care/Dermatology
Improve Skin Health and Boost Consumer Confidence with Metabolomics
The architecture of our skin is unique and complex, providing a protective barrier to prevent water loss and safeguard against environmental stressors (e.g. heat/humidity, pollution), microbes, toxins, and UV radiation. Cellular damage, aging, and disease can all be assessed with metabolomics through changes in amino acids, lipids, energy metabolism, osmolytes, and natural moisturizing factors. Assessing the role metabolites play in these pathways can enhance understanding of the underlying mechanisms driving skin-related diseases/conditions and enable improved development of effective therapeutics, as well as skin care and beauty products.
Human Health and Nutrition
Metabolomics is the Language of Life and Health
Nutrition, impacting energy production, growth and development, tissue repair, cell growth, immune function, disease prevention, cognitive function, weight management, and bone health, plays a vital role in health, ensuring that the body functions properly and maintains optimal well-being. Metabolomics is uniquely positioned to help advance nutritional science as it provides valuable insights into how nutrients and dietary patterns affect the body’s metabolism and overall health, from infant health to senior nutrition. Metabolomics can be used to assess nutritional value, determine relationships between nutrients and health, evaluate the impact of dietary interventions (e.g., foods, supplements, vitamins, probiotics, lifestyle modifications, etc.) on an individual’s metabolomic phenotype, study nutrient-drug interactions, and understand the contribution of diet and exercise on the intestinal microbiome.
“Critically, the specific metabolite pools responsive to differential fiber intake were dependent on differences both in individual microbial community membership and in overall ecological configuration. This helps to explain, for the first time, differences in microbiome-diet associations observed in companion animal epidemiology.”
Bhosle, A., Jackson, M. I., Walsh, A. M., Franzosa, E. A., Badri, D. V., & Huttenhower, C. (2025).
Response of the gut microbiome and metabolome to dietary fiber in healthy dogs. mSystems, 10(1): e00452-24.
Researchers from the Broad Institute, Harvard University, and Hill’s Pet Nutrition found that the type and amount of dietary fiber in dog food significantly alters the gut microbiome and fecal metabolome of healthy dogs, revealing that the production of beneficial metabolites depends on specific fiber–microbe interactions and varies by animal.
Featured Applied Markets Resources
On Demand Webinar: Advancing Drug Discovery with Metabolomics
On Demand Webinar: Leveraging Metabolomics for Biomarker Discovery in a Multiomics Landscape
Poster: Validation of Targeted Quantitative Analysis of Endogenous Biomarkers for Good Clinical Practice Studies
Featured Applied Markets Publications and Citations
Metabolon has contributed extensively to publications ranging from human nutrition to skin health.
Response of the gut microbiome and metabolome to dietary fiber in healthy dogs
Metabolomics helped to elucidate how different dietary fibers affect the gut microbiome and metabolite production in healthy dogs, revealing that specific fiber sources enriched distinct microbial species and metabolites. The results highlight that individual microbiome composition significantly shapes metabolic responses to fiber, supporting the concept of personalized nutrition even among similar animals.
Metabolomics Analysis Reveals Deranged Energy Metabolism and Amino Acid Metabolic Reprogramming in Dogs With Myxomatous Mitral Valve Disease.
Metabolomics identified biochemical pathways playing a role in canine degenerative mitral valve disease, the most common form of heart disease in dogs.
Multi-omics analysis to decipher the molecular link between chronic exposure to pollution and human skin dysfunction
Using a multiomics approach (metabolomics, proteomics, and microbiome analyses), this study revealed how chronic exposure to air pollution alters human skin. The researchers found that pollution exposure correlates with distinct metabolite and microbiome profiles, and identified molecular signatures associated with skin barrier disruption, and pigmentary disorders.
Deciphering the Role of Skin Surface Microbiome in Skin Health: An Integrative Multiomics Approach Reveals Three Distinct Metabolite‒Microbe Clusters.
Using combined microbiome and metabolomics analyses of infant skin, this study identified distinct microbe–metabolite clusters linking specific bacterial genera to key aspects of skin physiology. Cutibacterium was associated with hydrophobic barrier components and Staphylococcus was associated with amino acids involved in hydration and pH balance.
Infants Fed Breastmilk or 2′-FL Supplemented Formula Have Similar Systemic Levels of Microbiota-Derived Secondary Bile Acids.
This randomized controlled study found that supplementing infant formula with the human milk oligosaccharide 2′-fucosyllactose (2′-FL) increased serum metabolites linked to gut microbial activity, particularly secondary bile acids, in a dose-dependent manner. The metabolic profiles of infants fed 2′-FL–fortified formula resembled those of breastfed infants, suggesting that HMO supplementation supports healthier gut microbiome–driven metabolism.
Early-Life Fecal Microbiome and Metabolome Dynamics in Response to an Intervention with Infant Formula Containing Specific Prebiotics and Postbiotics.
Applied Markets FAQs
Metabolon strives to ensure your metabolomics study is successful and offers key insights into your scientific questions. We support you at every step from study design to data delivery.
In What Ways is Metabolomics Applicable to Applied Markets Needs?
Metabolomics can be employed to address a variety of objectives in this space. The most common uses are to establish or support product marketing claims, identify and develop product improvement strategies (formulation, optimal regimen, competitor comparison), and discern how intelligent interventions (food, supplement, pre/pro/post-biotics, treatment, exercise, lifestyle modifications) can guide metabolic phenotypes. Additional examples of achievable goals include understanding the contribution of diet, disease, and/or treatment on the intestinal (or skin) microbiome, biomarker identification (disease, treatment efficacy), elucidating product mechanism of action, toxicity and safety evaluation, and bioactive identification, among others.
What Unique Value-Add Can Metabolomics Provide that Other Data Streams Can Not in the Applied Markets Space?
Metabolomics is exclusive in that it can provide the most direct readout of phenotypic effects. In the Applied Markets world, proving that a product “works” is paramount, so providing scientific evidence to support a manufacturers claim is of high value. Examples of specific claims include, but are not limited to, improvements in oxidative stress, inflammation, energetics status, gut barrier function (e.g., permeability), microbiome health/diversity, organ function (e.g., liver, kidney), skin hydration, weight management, and product taste/quality.
What are the Most Common Matrices to Analyze in the Applied Markets Space?
Metabolon’s Global Discovery Panel is amenable to virtually any sample type. Common matrices employed in human and animal nutrition include plasma, serum, feces, saliva, and urine. Within the dermatology/cosmetology space, the primary sample types include D-squame, Sebutapes, skin biopsies, reconstituted human epidermis, and keratinocytes, although various biofluid samples can be analyzed as well depending on the therapeutic area and objective.
The Leading Untargeted Metabolomics Solution
Gain access to unrivaled data insights from our untargeted metabolomics service, leveraging the largest level 1 annotated library of metabolites for commercial use. Explore over 70 biochemical pathways and detect up to 5,400 metabolites in a single biological sample.
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