Why Metabolon?

Coverage

Metabolomics, the large-scale study of metabolites within cells, biofluids, tissues or organisms, is the definitive representation of the phenotype, providing a real-time assessment of health, wellness, and disease, whether influenced by genes, proteins, the environment, epigenetics, or the microbiome. Executed comprehensively, metabolomics provides life sciences researchers and drug developers with an integrated look at the functional state of a biological system, allowing you to quickly zero in on the biological insights and biomarkers that define health, disease, and treatment response.

Far too often, however, researchers and drug developers fail to benefit from the full power of metabolomics because they employ an incomplete metabolomics solution—one with limited coverage and interpretability—that leaves potentially transformational discoveries in the dark.

Poor Metabolomics Coverage Limits Biological Understanding

An essential part of a metabolomics research project is ensuring broad coverage of the metabolome and an understanding of the metabolic pathways involved, leading to a real actionable insight into what’s going on in the biological system. In-house metabolomics labs often search against publicly available databases to identify the liquid chromatography-mass spectrometry (LC/MS) peaks detected. This informatics approach means they get limited, poor confidence, and potentially incorrect compound identifications. Most in-house labs can identify 200 to 300 compounds. These limitations compromise the ability to derive biological understanding by not getting comprehensive and accurate coverage of the entire biological space.
Poor Metabolomics Coverage Limits Biological Understanding
Number of Peaks per Metabolite

Reveal Metabolites, Not Peaks

In addition to reference database limitations, metabolomics labs might also refer to the number of identified LC/MS peaks as metabolites. In reality, multiple peaks can make up one metabolite (See Figure), so while a given study might show thousands of peaks, the number of identified metabolites is in the hundreds. As you evaluate metabolomics solutions providers, you should base your decision regarding methodology on the number of high-quality identified metabolites, not the number of peaks.

Broad Coverage Leads to Actionable Insights

In contrast, Metabolon clients benefit from Metabolon’s informatics approach that relies on identifying LC/MS peaks based on a search of an in-house generated database of more than 5,400 biologically relevant small molecules. This compound database enables Metabolon to provide the greatest number of identified compounds with the highest possible confidence identifications in the industry; known as Metabolomics Standards Initiative. Metabolon’s broad coverage and adherence to the highest level of identification standards are crucial to understanding the biology and producing accurate, actionable insights. Read more about our approach to Tier 1 metabolite identifications here.

Broad Coverage Leads to Actionable Insights

See how Metabolon can advance your path to preclinical and clinical insights

Why Metabolon?

Once you see the full value of metabolomics, the only remaining question is who does it best? While many laboratories have metabolite profiling or analytical chemistry capabilities, comprehensive metabolomics technologies are extremely rare. Accurate, unbiased metabolite identification across the entire metabolome introduces signal-to-noise challenges that very few labs are equipped to handle. Also, translating massive quantities of data into actionable information is slow, if not impossible, for most because proper interpretation takes two things that are in short supply: experience and a comprehensive database.

Only Metabolon has all four core metabolomics capabilities

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Coverage

Ability to interrogate thousands of metabolites across diverse biochemical space, revealing new insights and opportunities

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Comparability

Ability to integrate the data from different studies into the same dataset, in different geographies, among different patients over time
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Competency

Ability to inform on proper study design, generate high‐quality data, derive biological insights, and make actionable recommendations
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Capacity

Ability to process hundreds of thousands of samples quickly and cost‐efficiently to service rapidly growing demand

Partner with Metabolon to access:

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A library of 5400+ known metabolites, 2000 in human plasma, all referenced in the context of biochemical pathways

  • That’s 5x the metabolites of the closest competitor
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Unparalleled depth and breadth of experience analyzing and interpreting metabolomic data to find meaningful results

  • 10,000+ projects with hundreds of clients
  • 2,000+ publications covering 500 diseases, including numerous peer-reviewed journals such as Cell, Nature and Science
  • Nearly 40 PhDs in data science, molecular biology, and biochemistry

Using our robust platform and visualization tools, our experts are uniquely able to tell you more about your molecule and develop assay panels to help you zero in on the results you need.

Contact Us

Talk with an expert

Request a quote for our services or more information on sample types and handling procedures, need a letter of support, or simply have questions about how metabolomics can advance your research.

Corporate Headquarters

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Mailing Address:
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+1 (919) 572-1711

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International Headquarters

Metabolon GmbH

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