Respiratory Disorders are Life-Threatening
The Complexity of Respiratory Diseases Requires a Personalized Approach
Metabolomics Works On Many Sample Types
Metabolon’s technology provides a high-fidelity and reproducible analysis of a biological sample’s metabolomic profile. Metabolomics can uniquely provide details of perturbations in fundamental biochemical pathways or mechanisms and the identification of novel biochemical processes. Global metabolomics can be applied to cultured cells, tissues from model organisms, and patient biopsies to discover novel metabolic drivers of biological processes. These insights can be translated into actionable biomarkers for respiratory diseases through follow-on targeted panels. Metabolon therefore can aid in the discovery of biomarkers that will aid the diagnosis and treatment of respiratory disorders with greater sensitivity, specificity, and precision.
Metabolon—From Biomarkers to Drug Development
See how Metabolon can advance your path to preclinical and clinical insights
Metabolomics Panels for Respiratory Disorders
Amino Acids Targeted Panel
Bile Acids Targeted Panel
Central Carbons Targeted Panel
Free Fatty Acids Targeted Panel
Salivary Glucose Single Analyte Assay
Indoles/Uremic Toxicity Targeted Panel
Metal Analysis Targeted Panel
Short Chain Fatty Acids Targeted Panel
Tryptophan/Kynurenine Ratio Targeted Panel
The kynurenine/tryptophan ratio has been used to reflect the activity of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in cellular inflammatory response related to symptoms of depression, schizophrenia, and other neurological disease.
Metabolon in Action
Identify a key pathway in lung cancer epithelial to mesenchymal transition (EMT) and drug resistance
Identification of Therapeutic Target for a Rare Disease Lymphangioleiomyomatosis (LAM)
The Metabolon Global Discovery Panel identified an increase in prostaglandins in TSC2-deficient cells after estradiol treatment, pointing to COX-2 as a therapeutic target for lymphangioleiomyomatosis.
Side Effects of Inhaled Glucocorticoids (GCs) for Asthma Treatment
Results from this study showed that inhaled GCs induce significant changes in several biochemical pathways only at high and supratherapeutic doses, thus supporting the safety of low and mid therapeutic doses.
Interested in Further Studies?
Once you see the full value of metabolomics, the only remaining question is who does it best? While many laboratories have metabolite profiling or analytical chemistry capabilities, comprehensive metabolomics technologies are extremely rare. Accurate, unbiased metabolite identification across the entire metabolome introduces signal-to-noise challenges that very few labs are equipped to handle. Also, translating massive quantities of data into actionable information is slow, if not impossible, for most because proper interpretation takes two things that are in short supply: experience and a comprehensive database.
Only Metabolon has all four core metabolomics capabilities
Ability to interrogate thousands of metabolites across diverse biochemical space, revealing new insights and opportunities
Ability to integrate the data from different studies into the same dataset, in different geographies, among different patients over time
Ability to inform on proper study design, generate high‐quality data, derive biological insights, and make actionable recommendations
Ability to process hundreds of thousands of samples quickly and cost‐efficiently to service rapidly growing demand
Partner with Metabolon to access:
A library of 5,400+ known metabolites, 2,000 in human plasma, all referenced in the context of biochemical pathways
- That’s 5x the metabolites of the closest competitor
Unparalleled depth and breadth of experience analyzing and interpreting metabolomic data to find meaningful results
- 10,000+ projects with hundreds of clients
- 2,000+ publications covering 500 diseases, including numerous peer-reviewed journals such as Cell, Nature and Science
- Nearly 40 PhDs in data science, molecular biology, and biochemistry
Using our robust platform and visualization tools, our experts are uniquely able to tell you more about your molecule and develop assay panels to help you zero in on the results you need.
Related Metabolomics Resources
Talk with an expert
Request a quote for our services, get more information on sample types and handling procedures, request a letter of support, or submit a question about how metabolomics can advance your research.
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Morrisville, NC 27560
P.O. Box 110407
Research Triangle Park, NC 27709
+1 (919) 572-1711