Metabolon Target
Indoles/Uremic Toxicity Targeted Panel
6 Metabolites
Absolute Quantitation
Rigorous Quality Control
End-to-end Service
About Indoles and Uremic Toxicity
Metabolomics reveals biological insights otherwise unseen. For a successful metabolomics study, both small molecule discovery and the ability to dig deeper into specific biomarkers of interest are needed to uncover actionable insights that propel new therapeutic developments. A specific combination of liquid chromatography-mass spectrometry (LC-MS) technology and biochemical expertise is required to identify these biomarkers of interest and develop assays that are sensitive enough to explore them fully.
At Metabolon, we understand the crucial role indoles play in kidney disease, and we’ve established best-in-class expertise for their detection. This panel focuses on specific indoles and their metabolic pathways and can be used to track biomarkers and enhance biological understanding across preclinical and clinical research.
Indoles/Uremic Toxicity Targeted Panel Details
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| LLOQ* | |
|---|---|
| Metabolite | Plasma/Serum |
| 4-Ethylphenyl sulfate | 1.00 ng/mL |
| p-Cresol sulfate | 5.00 ng/mL |
| 3-Indoxyl sulfate | 10.0 ng/mL |
| Tryptophan | 500 ng/mL |
| 3-Indolelactic acid | 10.0 ng/mL |
| 3-Indolepropionic acid | 7.50 ng/mL |
Analysis Method and Instrumentation:
LC-MS/MS (Agilent 1290 UHPLC/Sciex QTrap 5500)
| Sample Type and Required Amounts | |
|---|---|
| Sample Type | Sample Requirements |
| Plasma | ≥ 150 µL |
Others on request
Disclaimer: This method is for Research Use Only and is not to be used for diagnostic purposes.
Delivering Absolute Quantification for Research and Biomarker Analysis
Our readily available or custom developed quantitative assays help you achieve your research and biomarker validation objectives with precise and fully validated methods. Our targeted assays and panels cover >1,000 metabolites and lipids across a wide range of biochemical classes, metabolic pathways, and physiological processes, and they can be customized to best fit any application.
Indoles/Uremic Toxicity Targeted Panel Applications
Kidney
The kidneys are essential for the elimination of waste products, the regulation of osmolality and blood pressure, pH homeostasis, and the secretion of certain hormones. Chronic kidney disease (CKD) often occurs as a result of other diseases, such as diabetes or high blood pressure. The Targeted Panel team at Metabolon has developed multiple assays that can provide insights into the function of renal and urological tissue, such as the Creatinine Assay, Indoles/Uremic Toxicity Panel, and the Metal Cofactors and Toxic Metals Assay.
Gut Health
Neuroscience
COVID
Recognized for our cutting-edge approach to metabolomics, Metabolon has been a valued resource for COVID-19 researchers worldwide. Our actionable metabolomic insights have fueled pivotal and high-profile studies like the National Institute of Allergy and Infectious Diseases (NIAID) IMPACC study research to improve understanding of high-risk patients and the Institute for Systems Biology research to improve understanding of high-risk patients. These and other metabolomics projects with actionable insights at Metabolon are helping get closer to the phenotype and pressing forward on COVID-19 answers.
Big Insights with Metabolon
Cited in over 3,000 publications, we help scientists and manufacturers gain greater insight into their studies through metabolomics. See how our approach can become a successful part of your workflow.
Related Metabolomics Resources
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