Metagenomic Sequencing
Pair Metagenomic Sequencing with Metabolomics for a Complete View of Microbiome Function
Integrating metagenomics sequencing with metabolomics links microbial composition to functional outputs to drive a deeper understanding of microbiome impact on host health.
- Flexile Sequencing Options
- Powerful Bioinformatics Tools for Data Integration
- Metabolites as a Phenotypic Output of the Microbial Community Composition
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Multiomic Microbiome Analysis
Reveal the Impact of the Microbiome on Host Health
The microbiome is now widely recognized as a key driver of human health, significantly impacting immunity, metabolism, and disease susceptibility. As a result, microbiome biology has rightfully become a key focus across diverse fields of biomedical research. A critical tool in this field is metagenomic sequencing, which has long been used to assess the composition of microbial communities and, more recently, to characterize the microbiome’s gene-coding potential through deep shotgun sequencing.
While metagenomics identifies microbial species and their genetic potential, it does not capture their functional contributions—what they are actively metabolizing—that affects the host. Metabolomics, the measure of the small molecule repertoire present in a sample, addresses this gap by providing a phenotypic readout of microbiome activity. By integrating metagenomics with metabolomics, researchers can gain a deeper understanding of microbial composition, function and its impact on host health.
Metagenomic Sequencing Options
Selecting the right metagenomic sequencing option is essential for achieving study goals while balancing cost and the depth of insights needed to answer your research questions. Metabolon offers multiple metagenomics sequencing options, including 16S Amplicon Sequencing and Shotgun Sequencing at various depths optimized for fecal samples. Learn more about our sequencing options here. By deeply understanding a study’s objectives and budget, Metabolon can help select the metagenomics sequencing option that delivers the best value and insights to advance your research goals.
Amplicon (16S) Sequencing
Amplicon sequencing enables microbial community composition evaluation by sequencing characteristic regions of the 16S rRNA gene to classify archaea and bacteria.
Shotgun Sequencing, Shallow (3 Million Reads)
For preliminary research or studies focused on broad microbial trends, the Shallow option can often be sufficient to explore community composition and differences across groups. This option provides a cost-effective means to obtain adequate data to identify dominant species and patterns.
Shotgun Sequencing, Balance (15 Million Reads)
The Balance option offers a good balance between cost and depth of insights. This option provides an overview of both dominant and some less abundant species and begins to represent the gene function potential encoded by the microbial community.
Shotgun Sequencing, Deep (20 Million Reads)
For detecting rare microbial species or performing highly detailed gene function analyses, the Deep and Ultra Deep options provide the highest levels of detail. The Deep option provides in-depth coverage to capture more species diversity, rare microbes and rare gene functions.
Shotgun Sequencing, Ultra Deep (80 Million Reads)
This option provides ultra-high resolution, capable of capturing rare species, rare genes, and subtle functional differences driven by small variations in gene sequence. This option can most benefit researchers who have their own bioinformatics team to most fully leverage functional information available in this depth of data.
Our Microbiome Research Solution
Metabolon’s Microbiome Research Solution is a complete full-service offering for high-quality metabolomics and metagenomics data generation, user-friendly multiomic data analysis, and biological interpretation that can accelerate your microbiome research.
Global Discovery Panel
Metabolon’s metabolomics technology can detect and identify up to 5,400 metabolites in a single biological sample.
Microbiome Panel
A highly-curated metabolomics panel that screens for over 400 key small molecules to accelerate microbiome discovery.
Microbiome Analysis Tool
Unify metagenomic, metabolomic, and phenotypic data within a codeless, accessible platform that simplifies complex analyses.
Featured Resources
Learn more about how metabolomics and metagenomics can help you better understand the microbiome’s impact on health.
eBrochure: Global Discovery Panel
Live Webinar: Unravelling Microbiome Insights
Whitepaper: Guidance for Metagenomics Sequencing
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