COVID-19 Can Cause Serious Illness
How is Severity Associated with Demographics?
Currently, there are still major gaps in our understanding of how COVID-19 disease severity is associated with the host’s age, gender, and pre-existing conditions, limiting therapeutic options. The reasons behind the wide variability in individual responses to COVID-19 are poorly understood. This complexity calls for innovative ways to discover underlying pathologic pathways and to identify potential diagnostic and prognostic biomarkers of COVID-19. A better understanding of the host’s metabolic responses associated with COVID-19 is required to expand our knowledge about the pathogenesis of patients under different symptomatic conditions and to assist in the identification of disease biomarkers and the development of diagnostic panels, as well as possible therapeutic strategies.
Moreover, research has been faced with unprecedented circumstances due to the COVID-19 pandemic, limiting the ability of patients to access the lab for the collection of blood plasma, serum, and fecal samples. This dynamic has slowed or prevented many research programs globally.
Metabolomics Research Can Shed Light on Patient Response Pathways
Metabolon’s technology provides a high-fidelity and reproducible analysis of a biological sample’s (serum, plasma, stool sample, etc.) metabolomic profile. Metabolon offers the ability to understand what metabolites are changing in each individual patient in response to COVID-19 infection. These findings will elucidate how a patient’s age, gender, and pre-existing conditions correlate to metabolic changes and with COVID-19 severity and outcome. Global metabolomics offers the opportunity to profile thousands of biochemicals in an unbiased fashion to enable the discovery of novel disease mechanisms and biomarkers of COVID-19 severity and outcome.
Moreover, to continue to support your metabolomic research needs, including facilitating remote clinical trials, Metabolon has validated alternative sampling methods to meet decentralized testing location needs. These novel methods are an alternative to in-clinic visits, allowing monitoring of vulnerable patients and testing of remote populations without escalating sampling costs. For instance, Metabolon has validated the use of dried blood spot (DBS) cards for our metabolomics platform. This allows only a few drops of capillary blood from a finger to be tested for metabolic changes. Furthermore, through our collaboration with DNA Genotek, we found for the first time that the OMNImet®•GUT device can be used for room temperature collection of stool samples for metabolomics studies. This dramatically expands the accessibility of metabolomics for gut microbiome studies.
Metabolon has Validated Tests for Exploratory Research
See how Metabolon can advance your path to preclinical and clinical insights
Metabolomics Panels for COVID-19 Applications
Amino Acids Targeted Panel
Bile Acids Targeted Panel
Central Carbons Targeted Panel
Free Fatty Acids Targeted Panel
Salivary Glucose Single Analyte Assay
Indoles/Uremic Toxicity Targeted Panel
Metal Analysis Targeted Panel
Short Chain Fatty Acids Targeted Panel
Tryptophan/Kynurenine Ratio Targeted Panel
The kynurenine pathway is a metabolic pathway leading to the production of nicotinamide adenine dinucleotide (NAD+) from the enzymatic conversion of tryptophan. Immune activation leads to the formation of kynurenine with corresponding loss of tryptophan.
The kynurenine/tryptophan ratio has been used to reflect the activity of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in cellular inflammatory response related to symptoms of depression, schizophrenia, and other neurological disease.
Metabolon in Action
Sexual Dimorphism in COVID-19
The Global Discovery Panel assisted in the analysis of serum samples, showcasing hundreds of biochemicals affected by COVID-19 infection in biological males and females. 182 metabolites varied significantly between sexes, suggesting sex-specific metabolic differences in response to Covid-19 infection.
Circulating Lipids as COVID-19 Inflammatory Markers
The study’s findings demonstrate the potential of serum lipidomics to characterize the previously underappreciated role that lipids play in injury-induced acute critical illness. The results of the Metabolon Complex Lipids Panel revealed mechanisms contributing to worsened outcomes for patients hospitalized for acute critical illness.
Interested in Further Studies?
Once you see the full value of metabolomics, the only remaining question is who does it best? While many laboratories have metabolite profiling or analytical chemistry capabilities, comprehensive metabolomics technologies are extremely rare. Accurate, unbiased metabolite identification across the entire metabolome introduces signal-to-noise challenges that very few labs are equipped to handle. Also, translating massive quantities of data into actionable information is slow, if not impossible, for most because proper interpretation takes two things that are in short supply: experience and a comprehensive database.
Only Metabolon has all four core metabolomics capabilities
Ability to interrogate thousands of metabolites across diverse biochemical space, revealing new insights and opportunities
Ability to integrate the data from different studies into the same dataset, in different geographies, among different patients over time
Ability to inform on proper study design, generate high‐quality data, derive biological insights, and make actionable recommendations
Ability to process hundreds of thousands of samples quickly and cost‐efficiently to service rapidly growing demand
Partner with Metabolon to access:
A library of 5,400+ known metabolites, 2,000 in human plasma, all referenced in the context of biochemical pathways
- That’s 5x the metabolites of the closest competitor
Unparalleled depth and breadth of experience analyzing and interpreting metabolomic data to find meaningful results
- 10,000+ projects with hundreds of clients
- 2,000+ publications covering 500 diseases, including numerous peer-reviewed journals such as Cell, Nature and Science
- Nearly 40 PhDs in data science, molecular biology, and biochemistry
Using our robust platform and visualization tools, our experts are uniquely able to tell you more about your molecule and develop assay panels to help you zero in on the results you need.
Related COVID-19 Metabolomics Resources
Talk with an expert
Request a quote for our services, get more information on sample types and handling procedures, request a letter of support, or submit a question about how metabolomics can advance your research.
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Morrisville, NC 27560
P.O. Box 110407
Research Triangle Park, NC 27709
+1 (919) 572-1711