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Metabolomics Analysis

Metabolomics provides a unique, real-time fingerprint of your biological system to reveal novel discoveries and realize the promise of precision medicine.

New to metabolomics? Start here:

Amino Acids Targeted Panel

Your Introductory Guide to Metabolomics

This is a comprehensive guide developed to teach you the ins and outs of one of the most powerful omics tools in any scientist’s toolbox, one that can complement any existing workflow and help realize the full potential of other omics methods: metabolomics.

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metabolomics study design

Designing a Successful Metabolomics Study

In this series, we walk you through everything you need to know to ensure the success of your metabolomics study, including what to expect when working with Metabolon, at every step of the way—from designing your study to interpreting your data.
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Metabolites

Metabolite Encyclopedia

Metabolites have a wide range of functions, including cell growth support, defense and inhibition, and stimulation. They include amino acids, alcohols, vitamins, polyols, organic acids, and many other types of molecules, and are often the building blocks for larger compounds.

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Drug Development Metabolomics

Identify, clarify, confirm

Novel drug development is riddled with scientific uncertainties and financial risk. Metabolomics can improve your program’s chance for success by providing a comprehensive methodology to precisely illuminate the impact of your molecule in vivo and accelerate the drug development process.

peakmark

Identify novel pharmacodynamic, efficacy, and response biomarkers

peakmark

Clarify or define the mechanism of action (MOA)

peakmark

Triangulate upstream gene expression and downstream metabolite function to confirm individual biochemical pathways in response to your molecule

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Female Mass Spectrometrist in Metabolomics Laboratory
Male Scientist Reviewing Sample Tubes in Metabolomics Lab

Microbiome Metabolomics

Crack the functional code

Genomic sequencing can reveal microbiome richness and diversity—which and how many microbes are present in a microbiome—but stops short of revealing how microbes behave or their interaction with the host. Metabolomics reveals the critical next level of understanding by providing an instantaneous snapshot of microbial function, its impact on the host, and response to therapeutic intervention.

Explore Our Microbiome Metabolomics Solutions
Genome-Wide Association Studies (GWAS)

Build a Disease Atlas

Determining gene function and ascertaining important allelic differences are great challenges in genomic research. Metabolites are a sensitive and strong link between genes and disease phenotypes. Genomics researchers who incorporate metabolomics into GWAS studies can identify the allelic differences that matter and their mechanistic role in complex traits. The use of metabolomics increases understanding of disease and helps identify new opportunities for therapeutic intervention.

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Clinicians analyzing data

Related Metabolomics Resources

See All Metabolomics Resources

Enlighten your research, accelerate your discovery.

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Talk with an expert

Request a quote for our services, get more information on sample types and handling procedures, request a letter of support, or submit a question about how metabolomics can advance your research.

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Morrisville, NC 27560

Mailing Address:
P.O. Box 110407
Research Triangle Park, NC 27709

+1 (919) 572-1711

+1 (919) 572-1721

International Headquarters

Metabolon GmbH

Zeppelinstraße 3
85399 Hallbergmoos
Germany

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References

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2. Bryant, J.A., et al., The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome. Nat Med, 2026. 32(1): p. 186-196

3. McGovern, B .H., et al., SER-109, an Investigational Microbiome Drugto Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial. Clin Infect Dis, 2021. 72(12): p. 2132-2140.

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6. Butler, F.M., et al., Vegetarian Dietary Patterns and Diet-Related Metabolites Are Associated With Kidney Function in the Adventist Health Study-2 Cohort. J Ren Nutr, 2025.

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9. Fritsch, D.A., et al., Microbiome function underpins the efficacy of a fiber-supplemented dietary intervention in dogs with chronic large bowel diarrhea. BMC Vet Res, 2022. 18(1): p. 245.

10. Leal, L.N., et al., Preweaning nutrient supply improves lactation productivity and reduces the risk of culling in Holstein cows. J Dairy Sci, 2025. 108(6): p. 5875-5888.

11. Ahsin, M., et al., Soil and pasture health underlie improved beef nutrient density determined by untargeted metabolomics in Southern US grass finished beef systems. NPJ Sci Food, 2025. 9(1): p. 151.

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13. Porter, F .D., et al., Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Sci Transl Med, 2010. 2(56): p. 56ra81.

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15. Li, C., et al., Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. J Exp Med, 2014. 211(1): p. 15-28.

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17. Maekawa, H., et al., SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress. J Clin Invest, 2025. 135(19).

18. Wu, D., et al., Integrated screens reveal that guanine nucleotide depletion, which is irreversible via targeting IMPDH2, inhibits pancreatic cancer and potentiates KRAS inhibition. Gut, 2026.

19. Schwerdtfeger, L.A., et al., Gut microbiota and metabolites are linked to disease progression in multiple sclerosis. Cell Rep Med, 2025. 6(4): p. 102055.

20. Wu, H., et al., Microbiome-metabolome dynamics associated with impaired glucose control and responses to lifestyle changes. Nat Med, 2025. 31(7): p. 2222-2231.

21. Jacobs, J.P., et al., Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement. Microbiome, 2021. 9(1): p. 236.

22. Pietzner, M., et al., Plasma metabolites to profile pathways in noncommunicable disease multimorbidity. Nat Med, 2021. 27(3): p. 471-479.

23. Faquih, T.O., et al., Robust Metabolomic Age Prediction Based on a Wide Selection of Metabolites. J Gerontol A Biol Sci Med Sci, 2025. 80(3).

24. Scherer, N., et al., Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits. Nat Genet, 2025. 57(1): p. 193-205.

25. Holmes, Z.C., et al., Untargeted metabolomic analysis of human milk from healthy mothers reveals drivers of metabolite variability. Sci Rep, 2024. 14(1): p. 20827.

26. Titz, B., et al., Implications of Ocular Confounding Factors for Aqueous Humor Proteomic and Metabolomic Analyses in Retinal Diseases. Transl Vis Sci Technol, 2024. 13(6): p. 17.

27. Bloom, S.M., et al., Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation. Nat Microbiol, 2022. 7(3): p. 434-450.

28. Leimer, E.M., et al., Lipid profile of human synovial fluid following intra-articular ankle fracture. J Orthop Res, 2017. 35(3): p. 657-666.