Bile Acids Targeted Panel

Metabolon Target

Stratum Corneum Targeted Panel

R Absolute Quantitation

R Rigorous Quality Control

R End-to-end Service

About Stratum Corneum

The stratum corneum possesses a diverse biochemical composition, including a variety of lipids that contribute to its important role in skin barrier function and water retention. When these functions are disrupted, it can lead to a variety of skin disorders such as psoriasis, dandruff, and eczema. Utilizing metabolomics to measure the biochemical changes in the stratum corneum enables a deeper understanding of these and other skin conditions and offers improved monitoring of response to therapeutic intervention.

Metabolomics reveals biological insights otherwise unseen. For a successful metabolomics study, both small molecule discovery and the ability to dig deeper into specific biomarkers of interest are needed to uncover actionable insights that propel new therapeutic developments. A specific combination of liquid chromatography-mass spectrometry (LC-MS) technology and expertise is required to identify these biomarkers of interest and develop assays that are sensitive enough to explore them fully.

At Metabolon, we understand the crucial role lipids play in skin disorders, and we’ve established best-in-class expertise for their detection. This panel focuses on specific lipids and their metabolic pathways and can be used to track biomarkers and enhance biological understanding across clinical research.

Stratum Corneum Targeted Panel Details

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Sphingoid Base Fatty Acid Class
Ceramides alpha-hydroxy fatty acids (AS)
esterified omega fatty acids (EOS)
saturated fatty acids (NS)
Dihydro-ceramides alpha-hydroxy fatty acids (ADS)
saturated fatty acids (NDS)
6-Hydroxy-ceramides alpha-hydroxy fatty acids (AH)
esterified omega fatty acids (EOH)
saturated fatty acids (NH)
Phyto-ceramides alpha-hydroxy fatty acids (AP)
saturated fatty acids (NP)
Free Fatty Acids 16:0, 16:1, 18:0, 18:1, 18:2, 20:0, 20:1,
20:2, 22:0, 22:1, 24:0, 24:1
Sterols Cholesterol, Cholesterol Sulfate
Analysis Method and Instrumentation:
SF-/MS/MS (Waters UPC2/Sciex QTrap 5500)
Sample Type and Required Amounts
Sample Type Sample Requirements
Stratum Corneum 4 D-Squame disks
Skin cell cultures 5 million cells
Others on request

Disclaimer: This method is for Research Use Only and is not to be used for diagnostic purposes.

Delivering Absolute Quantification for Research and Biomarker Analysis

Our readily available or custom developed quantitative assays help you achieve your research and biomarker validation objectives with precise and fully validated methods. Our targeted assays and panels cover >1,000 metabolites and lipids across a wide range of biochemical classes, metabolic pathways, and physiological processes, and they can be customized to best fit any application.

Stratum Corneum Targeted Panel Applications

Personal Care & Cosmetics

Metabolon’s technology can provide a comprehensive survey of the skin metabolome and microbiome from a range of non-invasive skin sampling options, including our proprietary sample preparation process that allows subjects to provide samples using commercially available tape strips. In addition to our global Precision Metabolomics platform, we can quantitatively measure hundreds of lipid analytes on our pre-existing skin lipid panels. With the ability to capture biomarkers of wound repair, UV exposure, hydration, environmental exposures, and more, our proprietary platform has helped researchers understand skin conditions as diverse as dandruff, atopic dermatitis, psoriasis, acne, and aging.
Personal Care & Cosmetics

Big Insights with Metabolon

Cited in over 3,000 publications, we help scientists and manufacturers gain greater insight into their studies through metabolomics. See how our approach can become a successful part of your workflow.

Contact Us

Talk with an expert

Request a quote for our services or more information on sample types and handling procedures, need a letter of support, or simply have questions about how metabolomics can advance your research.

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