MyMetabolon Login
© 2020 Metabolon, Inc. All rights reserved.
Metabolon Metabolon
  • Metabolomics
    • About Metabolomics
    • Our Process
    • Technology & Knowledgebase
    • Setting the Standard: The 4Cs
    • Our Latest Insights
  • Solutions
    • Column 1
      • Products & Services
        • Global Metabolomics
        • Lipidomics
        • Targeted Assays
        • Study Design & Consulting
        • Sample Preparation & Handling
        • Study Success Sample Handling Kit
        • Reporting & Interpretation
        • Bioinformatics
        • MyMetabolon Client Portal
    • Column 2
      • By Research & Development Phase
        • Discovery & Target Selection
        • Lead Candidate Selection
        • Preclinical
        • Clinical Development
        • Manufacturing & Bioprocessing
    • Column 3
      • By Therapeutic Area
        • Cardiovascular Disease
        • COVID-19
        • Diabetes
        • Gastrointestinal
        • Liver Disease
        • Microbiome
        • Neuroscience
        • Oncology
        • Renal & Urological Disorders
        • Respiratory Disorders
    • Column 4
      • By Sector
        • Academic
        • Agriculture
        • Biotech / Pharmaceutical
        • Precision Medicine
        • Nutrition
        • Personal Care & Cosmetics
        • Population Health
        • Veterinary & Animal Health
  • Insights
    • Our Latest Insights
    • Blog
    • News & Events
  • Resources
    • Resource Library
    • Client Stories
    • COVID-19
  • Company
    • About Us
    • Working With Us (FAQ)
    • Leadership
    • Careers
    • Strategic Partnering
    • News & Events
    • Contact Us
MyMetabolon
Demo Our Data
Metabolon
Demo Our Data

Diabetes

A multi-focal view of metabolic disease

Diabetes, a serious metabolic condition that results from the inability to regulate blood sugar levels, is a worldwide epidemic. According to the Diabetes Research Institute Foundation, more than 30 million Americans and 422 million people worldwide have been diagnosed with diabetes. Yet much remains unknown about how diabetes develops, why certain individuals are at increased risk, and whether the metabolic dysregulation can be corrected rather than merely managed.

Metabolomics enables simultaneous assessment of hundreds of compounds present in living systems, making it a critical tool that advances our understanding of disease mechanism and opens doors to identify novel targets and treatments for conditions like diabetes.

TALK WITH AN EXPERT
See More Solutions
Reveal disease mechanisms and support patient stratification

Measuring changes in metabolites – small molecules present in the blood – using metabolomics can provide clues into how the disease develops while revealing potential new treatment avenues.

Metabolon has revealed insights about the mechanisms contributing to the development of Type 2 diabetes (T2D). Most recently, our technology contributed to the identification of a key gut microbiome-derived compound linked to insulin resistance. The study by Koh et al. helps us better understand how the gut microbiome affects the host’s physiology and provides the basis for a novel treatment strategy. Unraveling disease mechanisms is also vital to understanding related conditions like prediabetes and gestational diabetes. Since both may signal a predisposition to developing a form of T2D, diabetes researchers will find value in the capability of Metabolon’s metabolomics and lipidomics services for discovering predictive biomarkers. With these tools, Metabolon is uniquely positioned to capture diabetes phenotypes through the broadest lens possible.

Understand treatment mode of action

Metabolomics has helped elucidate the mode of action of metformin, the front-line drug for T2D. We know that metformin reduces insulin resistance and improves the uptake of glucose in muscle. You might be surprised to learn that it also reduces the risk of cancer and lowers the values of LDL cholesterol.1 However, the mode of action of metformin on its many target organs is still not completely understood. Recently, metabolomics helped to show that the drug relaxes smooth muscle, thereby aiding T2D patients who also have cardiovascular disease. Better understanding of how metformin works could improve treatments for diabetic patients and identify additional therapeutic uses. More broadly, this research demonstrates the power of metabolomics in understanding therapeutic mode of action in diabetes and its comorbidities.

Metabolomics can provide a snapshot of the metabolic state of the entire organism as well as individual tissues, revealing how metabolic disease can drive inflammatory disorders and other comorbidities.

1. Adam J et al., Metformin Effect on Nontargeted Metabolite Profiles in Patients with Type 2 Diabetes and in Multiple Murine Tissues. Diabetes. 2016 Dec;65(12):3776-3785.

Study Design

Data Interpretation

Our Platform

Learn More

Related Resources

See All Resources
How Metabolomics is Uncovering a Greater Understanding of Cardiometabolic Diseases

How Metabolomics is Uncovering a Greater Understanding of Cardiometabolic Diseases

Cardiovascular Disease, Global Metabolomics, Metabolic Disease, Microbiome, Webinars
Global Metabolomics & Diabetes: Stories from the Bench to the Clinic

Global Metabolomics & Diabetes: Stories from the Bench to the Clinic

Biotech / Pharmaceutical, Clinical Development, Discovery & Target Selection, Global Metabolomics, Lead Candidate Selection, Metabolic Disease, Preclinical, Webinars
How Metabolomic Profiling Can Unlock Gene Function & Provide Biological Insight

How Metabolomic Profiling Can Unlock Gene Function & Provide Biological Insight

Cardiovascular Disease, Global Metabolomics, Metabolic Disease, Multi-Omics Integration, Webinars
Load more

Enlighten your research,
accelerate your discovery.

Demo Our Data
or Talk With an Expert

Metabolomics

  • About Metabolomics
  • Our Process
  • Technology & Knowledgebase
  • Setting the Standard: The 4Cs
  • Insights & Discoveries

Solutions

  • Products & Services
  • By Research & Development Phase
  • By Therapeutic Area
  • By Sector

Insights

  • Our Latest Insights
  • Blog
  • News & Events

Resources

  • Resource Library
  • Client Stories
  • COVID-19

Company

  • About Us
  • Working With Us (FAQ)
  • Leadership
  • Careers
  • Strategic Partnering
  • News & Events
  • Contact Us
Metabolon - Logo - Enlightening Life

Metabolon provides actionable biological insights to answer the toughest questions in life sciences research and drug development.

© 2021 Metabolon, Inc. All rights reserved. Privacy & Terms

in
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept”, you consent to the use of ALL the cookies.
Cookie settingsACCEPT
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled

Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.

Non-necessary

Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.