With more than 20 validated panels and single analyte assays providing absolute, reproducible quantification for more than 450 biochemicals in a variety of different matrices, Metabolon provides the best possible coverage for analytes and biomarkers of significance for all applications and therapeutic areas.
When you purchase any Metabolon Target targeted panel or assay, you benefit from the rigor and expertise of Metabolon’s metabolomics specialists. Every method is fully validated covering precision, accuracy, extraction recovery, carryover, selectivity, benchtop stability, and freeze/thaw stability. This enables you to be confident in the quality and reliable nature of your data, letting you focus on identifying important scientific insights.
The table below is a summary of our most popular validated panels, providing quantification for a series of analytes and biomarkers in various sample types.
(Scroll left/right to see full table)
| Service Name | Biomarkers | Cells | Tissue | Plasma | Serum | Urine | Feces | Feces (OMNImet®•GUT tubes) | Dried Blood Spots | Saliva | Sebum (Sebutape® strips) | Stratum Corneum (D-Squame® discs) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amino Acids Targeted Panel | 22 | ✓ | ✓ | |||||||||
| Beta-hydroxybutyrate (BHBA) Single Analyte Assay | 1 | ✓ | ✓ | |||||||||
| Bile Acids Targeted Panel | 21 | ✓ | ✓ | ✓ | ✓ | ✓ | ||||||
| C4 Single Analyte Assay | 1 | ✓ | ✓ | |||||||||
| Cannabinoids Targeted Panel | 31 | ✓ | ||||||||||
| Central Carbons Targeted Panel | 7 | ✓ | ✓ | ✓ | ✓ | |||||||
| Complex Lipids Targeted Panel | 1100 | ✓ | ✓ | ✓ | ✓ | ✓ | ||||||
| Creatinine Single Analyte Assay | 1 | ✓ | ✓ | ✓ | ||||||||
| Diabetes Research Markers Targeted Panel | 22 | ✓ | ||||||||||
| Fatty Acids Metabolism Targeted Panel | 26 | ✓ | ✓ | |||||||||
| Free Fatty Acids Targeted Panel | 7 | ✓ | ✓ | ✓ | ||||||||
| Impaired Glucose Tolerance Targeted Panel | 8 | ✓ | ||||||||||
| Indoles/Uremic Toxicity Targeted Panel | 6 | ✓ | ✓ | |||||||||
| Insulin Resistance Targeted Panel | 4 | ✓ | ||||||||||
| Lipid Mediators of Inflammation Targeted Panel | 57 | ✓ | ||||||||||
| Metal Analysis Targeted Panel | 23 | ✓ | ✓ | ✓ | ||||||||
| Oxysterols Targeted Panel | 12 | ✓ | ||||||||||
| Salivary Glucose Single Analyte Assay | 1 | ✓ | ||||||||||
| Sebum Targeted Panel | 944 | ✓ | ||||||||||
| Short Chain Fatty Acids Targeted Panel | 9 | ✓ | ✓ | ✓ | ✓ | |||||||
| Sphingolipids Targeted Panel | 56 | ✓ | ✓ | |||||||||
| Stratum Corneum Targeted Panel | 350 | ✓ | ✓ | |||||||||
| Tryptophan/Kynurenine Ratio Targeted Panel | 2 | ✓ | ✓ |
(Scroll left/right to see full table)
| Evaluated Parameters | Exploratory | RUO | GCP/GCLP |
|---|---|---|---|
| Linearity, Accuracy, and Precision of Calibration Standards | ✓ (1 run) | ✓ (3 runs) | ✓ (3 runs) |
| QC Precision Accuracy | ✓ (1 level, precision only) | ✓ (3 levels) | ✓ (3 levels) |
| Lower Limit of Quantitation | ✓ (1 run) | ✓ (3 runs) | ✓ (3 runs) |
| Selectivity | ✓ (1 run) | ✓ (3 runs) | ✓ (3 runs) |
| Carryover | ✓ (1 run) | ✓ (3 runs) | ✓ (3 runs) |
| Dilution Accuracy | ✕ | ✓ | ✓ |
| Extraction Recovery (also used to show accuracy) | ✕ | ✓ | ✓ |
| Sample Stability Testing – Benchtop Stability | ✕ | ✓ | ✓ |
| Sample Stability Testing – Freeze/Thaw Stability | ✕ | ✓ | ✓ |
| Secondary Instrument | ✕ | ✕ | ✓ |
| Parallelism | ✕ | ✕ | ✓ |
| Matrix Effect Testing | ✕ | ✕ | ✓ |
| Specificity | ✕ | ✕ | ✓ |
| Sample Stability Testing – Long-Term Stability | ✕ | ✕ | ✓ |
| Extract Stability Testing | ✕ | ✕ | ✓ |
| Run Injection Stability Testing | ✕ | ✕ | ✓ |
| Solution Stability Testing | ✕ | ✕ | ✓ |
| QA Review | ✕ | ✕ | ✓ |
Our readily available or custom developed quantitative assays help you achieve your research and biomarker validation objectives with precise and fully validated methods. Our targeted assays and panels cover more than 1,000 metabolites and lipids across a wide range of biochemical classes, metabolic pathways, and physiological processes, and they can be customized to best fit any application.
Metabolon offers three levels of sample validation: Exploratory (research-oriented, limited validation), RUO (Routine Use Only), and GCP/GCLP (Good Clinical Practice / Good Clinical Laboratory Practice).
All methods at Metabolon are validated to adhere to Metabolon’s ISO 9001:2015 certified quality system. Validation experiments are based on the FDA, EMA, and ICH M10 Bioanalytical Guidance documents. All data are peer-reviewed, and a summary report containing the results of the validation experiment is provided.
For GCP/GCLP validation, all experiments and acceptance criteria strictly adhere to the FDA, EMA, and ICH M10 Bioanalytical Guidances. All GCP/GCLP studies are peer-reviewed and audited by the Metabolon Quality Assurance Department. A validation report containing all of the elements listed in the M10 Bioanalytical Guidance is provided.
The table below outlines all evaluated analytical performance parameters for Exploratory, RUO, and GCP/GCLP standards.
Once you see the full value of metabolomics, the only remaining question is: who does it best? While many laboratories have metabolite profiling or analytical chemistry capabilities, comprehensive metabolomics technologies are extremely rare.
Accurate, unbiased metabolite identification across the entire metabolome introduces signal-to-noise challenges that very few labs are equipped to handle. Also, translating massive quantities of data into actionable information is slow, if not impossible, for most because proper interpretation takes two things that are in short supply: experience and a comprehensive database.
Using our robust platform and visualization tools, our experts are uniquely able to tell you more about your molecule and develop assay panels to help you zero in on the results you need.
Coverage
Ability to interrogate thousands of metabolites across diverse biochemical space, revealing new insights and opportunities
Comparability
Ability to integrate the data from different studies into the same dataset, in different geographies, among different patients over time
Competency
Ability to inform on proper study design, generate high‐quality data, derive biological insights, and make actionable recommendations
Capacity
Ability to process hundreds of thousands of samples quickly and cost‐efficiently to service rapidly growing demand
Request a quote for our services, get more information on sample types and handling procedures, request a letter of support, or submit a question about how metabolomics can advance your research.
Corporate Headquarters
617 Davis Drive, Suite 100
Morrisville, NC 27560
Mailing Address
P.O. Box 110407
Research Triangle Park, NC 27709
Phone
+1 (919) 572-1711
Fax
+1 (919) 572-1721
International Headquarters
Metabolon GmbH
Zeppelinstraße 3
85399 Hallbergmoos
Germany
