October 2023 Publication Summary of Studies Using Metabolon’s Panels and Services

In the month of October, Metabolon contributed to 38 studies that resulted in publications! Congratulations to the labs that published the following in high impact journals!

• Lundgren P, Sharma PV, Dohnalová L, et al. A subpopulation of lipogenic brown adipocytes drives thermogenic memory. Nature Metabolism. 2023/10/01 2023;5(10):1691-1705. doi:10.1038/s42255-023-00893-w
• Mandal RK, Mandal A, Denny JE, Namazii R, John CC, Schmidt NW. Gut Bacteroides act in a microbial consortium to cause susceptibility to severe malaria. Nature Communications. 2023/10/13 2023;14(1):6465. doi:10.1038/s41467-023-42235-0
• Almond M, Farne HA, Jackson MM, et al. Obesity dysregulates the pulmonary antiviral immune response. Nature Communications. 2023/10/19 2023;14(1):6607. doi:10.1038/s41467-023-42432-x
• Zhang X, Wang H, Kilpatrick LA, et al. Discrimination exposure impacts unhealthy processing of food cues: crosstalk between the brain and gut. Nature Mental Health. 2023/11/01 2023;1(11):841-852. doi:10.1038/s44220-023-00134-9
• Muhie S, Gautam A, Misganaw B, et al. Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder. Brain, Behavior, and Immunity. 2023/10/01/ 2023;113:303-316. doi:https://doi.org/10.1016/j.bbi.2023.07.015

October’s publications continue to highlight the integration of metabolomics with other omics to identify correlations to disease status. In several studies, metabolomics complemented additional experiments that sought to predict disease outcomes^2,15,28,36 or treat disease progression.⁷ One study presented a bioinformatics process that links clinical predictors to metabolic pathways and phenotypes.³³ In many studies, the focus is on metabolic pathways that contribute to disease; the next step is to identify a target within the pathway that might respond to treatment or work as a predictor. Combining omic technologies is quickly becoming the go-to approach in these cases. 

Humans, and the many environments we are exposed to, add significant complexity to biological processes, and the publications over the last month reiterate the complex nature of the many phenotypes and associated outcomes. Studies this month use case-control approaches and cohort or population studies to tease mechanisms apart. Studies in animals and cells are precursors to clinical trials. In all studies, Metabolon’s metabolomics services helped advance human knowledge and contribute to improving human health and well-being.  

For a convenient resource, you can access a searchable directory of metabolomics-related publications here.

Aging

1. Robinson O, Lau CE. How do metabolic processes age: Evidence from human metabolomic studies. Curr Opin Chem Biol. 2023;76:102360. doi:10.1016/j.cbpa.2023.102360
2. Chen Q, Dwaraka VB, Carreras-Gallo N, et al. OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records. bioRxiv. 2023:2023.10.16.562114. doi:10.1101/2023.10.16.562114
3. Hüfner K, Vedova S, Tymoszuk P, et al. The effect of inflammation, SARS-CoV-2 infection, age and mental health on serotonin, and kynurenine and catecholamine pathway metabolites. Psychoneuroendocrinology. 2023/10/01/ 2023;156:106334. doi:https://doi.org/10.1016/j.psyneuen.2023.106334

Cancer

4. Fujisawa K, Matsumoto T, Yamamoto N, Yamasaki T, Takami T. Metabolic Analysis of DFO-Resistant Huh7 Cells and Identification of Targets for Combination Therapy. Metabolites. 2023; 13(10):1073. https://doi.org/10.3390/metabo13101073
5. Zhong H, Liu S, Zhu J, Xu TH, Yu H, Wu L. Elucidating the role of blood metabolites on pancreatic cancer risk using two-sample Mendelian randomization analysis. International Journal of Cancer. 2023/10/20 2023;n/a(n/a)doi:https://doi.org/10.1002/ijc.34771
6. Miallot R, Millet V, Roger A, et al. The coenzyme A precursor pantethine enhances antitumor immunity in sarcoma. Life Science Alliance. 2023;6(12):e202302200. doi:10.26508/lsa.202302200
7. Li C, Zhang Y, Xia Q, et al. Multi-omics analysis revealed the mitochondrial-targeted drug combination to suppress the development of lung cancer. Journal of Cancer Research and Clinical Oncology. 2023/10/02 2023;doi:10.1007/s00432-023-05376-9
8. Mathur D, Liao C, Lin W, et al. The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung. Cancer Research. 2023;83(20):3478-3491. doi:10.1158/0008-5472.CAN-23-0153
9. Zhang T, Fu S, Yu K, et al. Nested Case–Control Studies Investigating Serum Perfluorooctanoate and Perfluorooctane Sulfonate Levels and Pancreatic Ductal Adenocarcinoma in Two Cohorts. Environmental Health Perspectives. 131(10):107702. doi:10.1289/EHP13208
10. Getz KR, Jeon MS, Luo C, Luo J, Toriola AT. Lipidome of mammographic breast density in premenopausal women. Breast Cancer Research. 2023/10/09 2023;25(1):121. doi:10.1186/s13058-023-01725-1

Cardiovascular Disease

11. Zambach C, Pan J, Gerward S, et al. The relationships between the plasma metabolome and orthostatic blood pressure responses. Scientific Reports. 2023/10/25 2023;13(1):18244. doi:10.1038/s41598-023-44226-z
12. Teunis CJ, Stroes ESG, Boekholdt SM, et al. Tryptophan metabolites and incident cardiovascular disease: The EPIC-Norfolk prospective population study. Atherosclerosis. 2023/10/20/ 2023:117344. doi:https://doi.org/10.1016/j.atherosclerosis.2023.117344
13. Freeman LM, Rush JE, Karlin ET. Untargeted metabolomic profiling of dogs with myxomatous mitral valve disease and congestive heart failure shows metabolic differences associated with the presence of cardiac cachexia. American Journal of Veterinary Research. 11 Oct. 2023 2023:1-10. doi:10.2460/ajvr.23.07.0161

Diabetes

14. Corbin LJ, Hughes DA, Bull CJ, et al. The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia. 2023/10/25 2023;doi:10.1007/s00125-023-06019-x
15. Carrasco-Zanini J, Pietzner M, Wheeler E, Kerrison ND, Langenberg C, Wareham NJ. Multi-omic prediction of incident type 2 diabetes. Diabetologia. 2023/10/27 2023;doi:10.1007/s00125-023-06027-x

Environment/Exposure

16. Rhee J, Loftfield E, Albanes D, et al. A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate. Environment International. 2023/10/01/ 2023;180:108198. doi:https://doi.org/10.1016/j.envint.2023.108198
17. Lundgren P, Sharma PV, Dohnalová L, et al. A subpopulation of lipogenic brown adipocytes drives thermogenic memory. Nature Metabolism. 2023/10/01 2023;5(10):1691-1705. doi:10.1038/s42255-023-00893-w

Women’s Health, Pregnancy, and Neonatal Health

18. Tobin NH, Murphy A, Li F, et al. Metabolomic profiling of preterm birth in pregnant women living with HIV. Metabolomics. 2023/10/25 2023;19(11):91. doi:10.1007/s11306-023-02055-1
19. Van JAD, Luo Y, Danska JS, et al. Postpartum defects in inflammatory response after gestational diabetes precede progression to type 2 diabetes: a nested case-control study within the SWIFT study. Metabolism. 2023/12/01/ 2023;149:155695. doi:https://doi.org/10.1016/j.metabol.2023.155695

Kidney Function

20. Sajid MI, Nunez FJ, Amirrad F, et al. Untargeted metabolomics analysis on kidney tissues from mice reveals potential hypoxia biomarkers. Scientific Reports. 2023/10/16 2023;13(1):17516. doi:10.1038/s41598-023-44629-y
21. Lee AM, Xu Y, Hooper SR, et al. Circulating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD. Clinical Journal of the American Society of Nephrology. 9900;

Liver Disease

22. Robles-Matos N, Radaelli E, Simmons RA, Bartolomei MS. Preconception and developmental DEHP exposure alter liver metabolism in a sex-dependent manner in adult mouse offspring. Toxicology. 2023/11/01/ 2023;499:153640. doi:https://doi.org/10.1016/j.tox.2023.153640
23. Johanns M, Haas JT, Raverdy V, et al. Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD. JHEP Reports. 2023/10/27/ 2023:100948. doi:https://doi.org/10.1016/j.jhepr.2023.100948

Microbiome

24. Cai W, Hadda M, Hadda R, et al. Gut microbiota promotes pain in fibromyalgia. bioRxiv. 2023:2023.10.24.563794. doi:10.1101/2023.10.24.563794
25. Mandal RK, Mandal A, Denny JE, Namazii R, John CC, Schmidt NW. Gut Bacteroides act in a microbial consortium to cause susceptibility to severe malaria. Nature Communications. 2023/10/13 2023;14(1):6465. doi:10.1038/s41467-023-42235-0

Neuroscience

26. Nguyen XTA, Le TNU, Ha HTT, et al. MFSD7c functions as a transporter of choline at the blood-brain barrier. bioRxiv. 2023:2023.10.03.560597. doi:10.1101/2023.10.03.560597
27. Loppi SH, Tavera-Garcia MA, Scholpa NE, et al. Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain. Preprints: Preprints; 2023.
28. Muhie S, Gautam A, Misganaw B, et al. Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder. Brain, Behavior, and Immunity. 2023/10/01/ 2023;113:303-316. doi:https://doi.org/10.1016/j.bbi.2023.07.015

Nutrition

29. Zhang X, Wang H, Kilpatrick LA, et al. Discrimination exposure impacts unhealthy processing of food cues: crosstalk between the brain and gut. Nature Mental Health. 2023/11/01 2023;1(11):841-852. doi:10.1038/s44220-023-00134-9
30. Costeira R, Evangelista L, Wilson R, et al. Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome. Clinical Epigenetics. 2023/10/19 2023;15(1):166. doi:10.1186/s13148-023-01578-7
31. Butler FM, Utt J, Mathew RO, et al. Plasma metabolomics profiles in Black and White participants of the Adventist Health Study-2 cohort. BMC Medicine. 2023/10/31 2023;21(1):408. doi:10.1186/s12916-023-03101-4
32. Martinez TM, Wachsmuth HR, Meyer RK, et al. Differential effects of plant-based flours on metabolic homeostasis and the gut microbiota in high-fat fed rats. Nutrition & Metabolism. 2023/10/19 2023;20(1):44. doi:10.1186/s12986-023-00767-8

Respiratory Disorders

33. Carpenter CM, Gillenwater L, Bowler R, Kechris K, Ghosh D. TreeKernel: interpretable kernel machine tests for interactions between -omics and clinical predictors with applications to metabolomics and COPD phenotypes. BMC Bioinformatics. 2023/10/25 2023;24(1):398. doi:10.1186/s12859-023-05459-x
34. Almond M, Farne HA, Jackson MM, et al. Obesity dysregulates the pulmonary antiviral immune response. Nature Communications. 2023/10/19 2023;14(1):6607. doi:10.1038/s41467-023-42432-x

Other

35. Zhao C, Su KJ, Wu C, et al. Multi-View Variational Autoencoder for Missing Value Imputation in Untargeted Metabolomics. Preprint. ArXiv. 2023;arXiv:2310.07990v1. Published 2023 Oct 12.
36. Scherer N, Fässler D, Borisov O, et al. Coupling of metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and resulting traits and diseases. medRxiv. 2023:2023.10.17.23297094. doi:10.1101/2023.10.17.23297094
37. Wadsworth BJ, Leiwe M, Minogue EA, et al. A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue. bioRxiv. 2023:2023.10.16.562554. doi:10.1101/2023.10.16.562554
38. Mishra N, Kant R, Goswami DG, et al. Metabolomics for identifying pathways involved in vesicating agent lewisite-induced corneal injury. Experimental Eye Research. 2023/11/01/ 2023;236:109672. doi:https://doi.org/10.1016/j.exer.2023.109672