In Support of Your Relentless Pursuit of Knowledge
Academic research is vital to gaining new insights and advancing our understanding of biological systems to improve the diagnosis, prevention, and treatment of disease. To accelerate academic research, metabolomics applications can be leveraged to capture the complexity of entire metabolic networks. From study design to sample collection and data analysis, Metabolon experts guide you every step of the way.
Metabolomics Captures the Whole Picture
Gene expression data and proteomic analyses provide useful information but do not fully capture the complexity of processes that occur in a cell, tissue, or organism. It is becoming more evident that genetic changes and subsequent alterations in protein activity and production have a direct relationship with metabolite levels. Metabolic profiling represents the next wave of academic research. This includes approaches that focus on profiling single pathways and holistic investigation that captures the complexity of entire metabolic networks. Studying metabolites and their changes provides insights that simple gene changes cannot predict.
20 Years of Metabolomic Expertise
As the newest omics branch, metabolomics is the most valuable approach to understanding the biochemical activities occurring within a sample (eg, plasma, serums, urine, saliva, tissues, and cells). Metabolomics can propel academic studies to new levels of insight in genetics, the microbiome, and multiple diseases. Metabolon provides the ability to make connections where other omics cannot.
Metabolon is committed to providing the highest quality metabolomics service to academic researchers, to aid in forging new paths to novel discoveries. We provide personalized partnership for study success at every stage of the process. Metabolon experts can guide you through experimental design, sample collection, report visualization, biological interpretation, and statistical analysis of metabolite profiles. Beginning with a study design consult, we set the stage for a successful study. Then, we offer guidance and tools for proper sample collection. Once samples have gone through our laboratory process, Discovery Panel reports may be visualized in the MyMetabolon portal.
Supporting Your Research and Publication Goals
Metabolon will help you design a study that answers your specific research questions to improve confidence, reduce the risk of failure, and make more informed decisions, to ultimately save you time. Our long history with academic research has resulted in more than 2000 peer-reviewed publications, many in high-impact journals, including Nature and Science. We have honed our expertise in applications of metabolomics through more than 10,000 studies, covering a comprehensive range of areas from cell biology discovery research to diabetes, obesity, cardiovascular disease, cancer, neuroscience, plant biology, microbiome, and many more. Our team of experts can also assist with letters of support, grant proposal resources, manuscript preparation, and expert interpretation to make your metabolomics study a success.
See how Metabolon can advance your path to preclinical and clinical insights
Metabolomics Panels for Academic Applications
Amino Acids Targeted Panel
Beta-Hydroxybutyrate Single Analyte Assay
β-Hydroxybutyrate (BHB, 3-hydroxybutyrate) is an endogenous ketone body that accumulates during periods of fasting, calorie restriction and prolonged exercise. It is created via a multi-step process involving the break-down of fatty acids into acetyl CoA, conversion to acetoacetate and reduction to β-hydroxybutyrate in the liver. BHB is the primary ketone found in the blood and is necessary for brain function especially when glucose is unavailable. It also provides neuroprotective benefits, such as relieving oxidative stress and inhibition of apoptotic pathway in cells.
Bile Acids Targeted Panel
C4 Single Analyte Assay
Central Carbons Targeted Panel
Free Fatty Acids Targeted Panel
Salivary Glucose Single Analyte Assay
Impaired Glucose Tolerance Targeted Panel
Impaired Glucose Tolerance is a prediabetic state of hyperglycemia that is associated with insulin resistance and an increased risk of cardiovascular pathology (Barr, 2007). The condition occurs when blood glucose levels remain high for an extended period after oral ingestion of glucose but not high enough to be diagnosed as type 2 diabetes.
Impaired Glucose Tolerance can be assessed with a single fasted blood draw by measuring a panel of selected metabolites comprised of two small organic acids (α-hydroxybutyric acid (AHB) and 4-methyl-2-oxopentanoic acid (4MOP)), 2 lipids (oleic acid and linoleoyl glycerophosphocholine (LGPC)), a ketone body (β-hydroxybutyric acid (BHBA)), an amino acid (serine), a vitamin (pantothenic acid (vitamin B5)), and glucose.
Insulin Resistance Targeted Panel
Insulin resistance is a critical pathophysiological state underlying several chronic conditions, including type-2 diabetes, cardiovascular disease (CVD), hypertension, and polycystic ovarian syndrome. Insulin resistance is evident when glucose builds up in the blood stream instead of being absorbed by the body’s cells. It is a result of a diminished response to the hormone insulin at the whole body, organ, or cellular level.
A panel of biomarkers comprised of a small organic acid (α-hydroxybutyric acid (AHB)), 2 lipids (oleic acid and linoleoylglycero-phosphocholine (LGPC)) and insulin identifies insulin resistance with a single fasting blood sample and may have value as an early indicator of risk for the development of prediabetes and type-2 diabetes.
Metal Analysis Targeted Panel
Metabolon in Action
Ketogenic Efficacy Through Microbiome Metabolism
A potential treatment for epilepsy without using probiotics is revealed through metabolomics following a ketogenic diet treatment. Metabolon identified hundreds of metabolites, with a large portion of those with significantly altered levels belonging to a class of metabolites called gamma-glutamyl amino acids (GG-AAs). The GG-AAs were found to be reduced in the mice fed a ketogenic diet, suggesting that GG-AA levels were significantly correlated to the number of seizures in the mouse model.
The Link Between Circadian Rhythm and Metabolic Disease
The relationship between coordination of peripheral clocks and pathology remains mostly unknown, but the circadian atlas, metabolic connections that regulate changes over time that are mediated by organ systems, demonstrates how global metabolomics is beginning to fill this information gap. Insightful works into the circadian rhythm have been fueled by metabolomics, revealing numerous findings to support health and disease management.
Interested in Further Studies?
Once you see the full value of metabolomics, the only remaining question is who does it best? While many laboratories have metabolite profiling or analytical chemistry capabilities, comprehensive metabolomics technologies are extremely rare. Accurate, unbiased metabolite identification across the entire metabolome introduces signal-to-noise challenges that very few labs are equipped to handle. Also, translating massive quantities of data into actionable information is slow, if not impossible, for most because proper interpretation takes two things that are in short supply: experience and a comprehensive database.
Only Metabolon has all four core metabolomics capabilities
Ability to interrogate thousands of metabolites across diverse biochemical space, revealing new insights and opportunities
Ability to integrate the data from different studies into the same dataset, in different geographies, among different patients over time
Ability to inform on proper study design, generate high‐quality data, derive biological insights, and make actionable recommendations
Ability to process hundreds of thousands of samples quickly and cost‐efficiently to service rapidly growing demand
Partner with Metabolon to access:
A library of 5,400+ known metabolites, 2,000 in human plasma, all referenced in the context of biochemical pathways
- That’s 5x the metabolites of the closest competitor
Unparalleled depth and breadth of experience analyzing and interpreting metabolomic data to find meaningful results
- 10,000+ projects with hundreds of clients
- 2,000+ publications covering 500 diseases, including numerous peer-reviewed journals such as Cell, Nature and Science
- Nearly 40 PhDs in data science, molecular biology, and biochemistry
Using our robust platform and visualization tools, our experts are uniquely able to tell you more about your molecule and develop assay panels to help you zero in on the results you need.
Related Academic Metabolomics Resources
Talk with an expert
Request a quote for our services, get more information on sample types and handling procedures, request a letter of support, or submit a question about how metabolomics can advance your research.
617 Davis Drive, Suite 100
Morrisville, NC 27560
P.O. Box 110407
Research Triangle Park, NC 27709
+1 (919) 572-1711