Assess Liver Health In Vivo
The liver is the single most important regulator of metabolic homeostasis at the organismal level in vertebrates and performs multiple crucial biological functions including detoxification of xenobiotics, protein metabolism, degradation of waste products, vitamin storage, and bile acid production. Metabolomics is an indispensable tool for capturing an integrative profile of an individual’s liver function. As the incidence of certain liver diseases, such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) continue to rise, researchers and healthcare providers can look to Metabolon to provide much-needed diagnostic and prognostic indicators to better understand the molecular mechanisms underpinning pathological processes. As the world leader in both metabolomics and lipidomics services, Metabolon is uniquely positioned to capture liver disease phenotypes through the broadest possible lens.
Approach the Disease Holistically
As there are no FDA-approved therapies specifically for NASH, diet and exercise are the main treatments. The lack of a clear disease taxonomy and deep mechanistic understanding of the disease is a major hindrance to drug development. Metabolon’s ability to non-invasively screen for thousands of metabolites in just one biological sample makes it an ideal solution for assessing the metabolic state. The metabolome integrates an individual’s genetic makeup, gene expression profile, and even nongenetic factors such as diet, environmental exposures, and the microbiome, making it the definitive representation of the phenotype. Therefore, layering metabolomic analysis onto genomic and transcriptomic data provides the best opportunity to understand disease.
Clarify Clinical Potential and Biomarker Strategy
Global untargeted metabolomics enables researchers to discover key changes or differences between conditions such as disease stages or drug treatments. This approach has the potential to produce not only fundamental insights into disease mechanisms, but also actionable biomarkers that can be used to track disease severity and therapeutic efficacy.
Build Future Diagnostics and Targets
See how Metabolon can advance your path to preclinical and clinical insights
Metabolomics Panels for Liver Disease Applications
Amino Acids Targeted Panel
Bile Acids Targeted Panel
C4 Single Analyte Assay
Central Carbons Targeted Panel
Free Fatty Acids Targeted Panel
Salivary Glucose Single Analyte Assay
Insulin Resistance Targeted Panel
Insulin resistance is a critical pathophysiological state underlying several chronic conditions, including type-2 diabetes, cardiovascular disease (CVD), hypertension, and polycystic ovarian syndrome. Insulin resistance is evident when glucose builds up in the blood stream instead of being absorbed by the body’s cells. It is a result of a diminished response to the hormone insulin at the whole body, organ, or cellular level.
A panel of biomarkers comprised of a small organic acid (α-hydroxybutyric acid (AHB)), 2 lipids (oleic acid and linoleoylglycero-phosphocholine (LGPC)) and insulin identifies insulin resistance with a single fasting blood sample and may have value as an early indicator of risk for the development of prediabetes and type-2 diabetes.
Metabolon in Action
Less Invasive Diagnostic Tools for NASH
Hepatitis B Virus Infection Dysregulates Lipid Biosynthesis Pathways
Early Screening for Urea Cycle Disorders (UCDs) in Plasma
In this study, metabolomic analysis of plasma identified several new potential biomarkers of UCDs. In addition to utility in helping in the screening for UCDs, this study suggests that untargeted metabolomics of plasma samples may be beneficial for monitoring the efficacy of medical treatment. Expanding newborn screening (NBS) for UCDs and shortening the turnout time are imperative in improving the sensitivity and specificity for screening these disorders.
Interested in Further Studies?
Once you see the full value of metabolomics, the only remaining question is who does it best? While many laboratories have metabolite profiling or analytical chemistry capabilities, comprehensive metabolomics technologies are extremely rare. Accurate, unbiased metabolite identification across the entire metabolome introduces signal-to-noise challenges that very few labs are equipped to handle. Also, translating massive quantities of data into actionable information is slow, if not impossible, for most because proper interpretation takes two things that are in short supply: experience and a comprehensive database.
Only Metabolon has all four core metabolomics capabilities
Ability to interrogate thousands of metabolites across diverse biochemical space, revealing new insights and opportunities
Ability to integrate the data from different studies into the same dataset, in different geographies, among different patients over time
Ability to inform on proper study design, generate high‐quality data, derive biological insights, and make actionable recommendations
Ability to process hundreds of thousands of samples quickly and cost‐efficiently to service rapidly growing demand
Partner with Metabolon to access:
A library of 5,400+ known metabolites, 2,000 in human plasma, all referenced in the context of biochemical pathways
- That’s 5x the metabolites of the closest competitor
Unparalleled depth and breadth of experience analyzing and interpreting metabolomic data to find meaningful results
- 10,000+ projects with hundreds of clients
- 2,000+ publications covering 500 diseases, including numerous peer-reviewed journals such as Cell, Nature and Science
- Nearly 40 PhDs in data science, molecular biology, and biochemistry
Using our robust platform and visualization tools, our experts are uniquely able to tell you more about your molecule and develop assay panels to help you zero in on the results you need.
Related Liver Disease Metabolomics Resources
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Request a quote for our services, get more information on sample types and handling procedures, request a letter of support, or submit a question about how metabolomics can advance your research.
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Research Triangle Park, NC 27709