December 2023 Publication Summary of Studies Using Metabolon’s Panels and Services

High Impact Journal Publications

1. Ohara Y, Tang W, Liu H, et al. SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer. Cell Rep. 2023;42(12):113434. doi:10.1016/j.celrep.2023.113434

A perpetual challenge in the study of brain function and related disorders is the difficulty in access to samples and the need for identification and validation of surrogate biomarkers that have the specificity and sensitivity for screening, diagnosis, and prognosis of biologically and/or clinically relevant phenotypic endpoints. For the month of December, Metabolon’s Global Discovery Platform and services supported studies in which the inclusion of metabolomics data was useful in identifying disease risk, cognition, aging, and the influence of weightlessness (space) on neural stem cell function. In addition, untargeted global metabolomics was useful in further supporting the linkage of microbial influence on brain function as part of the gut-brain-axis regulation.

For a convenient resource, you can access a searchable directory of metabolomics-related publications here.

Neurology

2. Yang C, Gorijala P, Timsina J, et al. Genetic analyses of the plasma proteome and metabolome in the same cohort from participants with African and European ancestry identify ancestry-specific AD risk associated molecular traits. Alzheimer’s & Dementia. 2023/12/01 2023;19(S12):e073687. doi:https://doi.org/10.1002/alz.073687
3. Gusdon AM, Savarraj JPJ, Redell JB, et al. Lysophospholipids Are Associated With Outcomes in Hospitalized Patients With Mild Traumatic Brain Injury. Journal of Neurotrauma. 2024/01/01 2023;41(1-2):59-72. doi:10.1089/neu.2023.0046
4. Palacios N. Metabolites and 12-Year Cognitive Measures Among a Cohort of Boston Area Puerto Ricans. Alzheimer’s & Dementia. 2023/12/01 2023;19(S15):e072142. doi:https://doi.org/10.1002/alz.072142
5. Gordon S, Koo B-B, Scott T, et al. Metabolites and Brain Age in a Puerto Rican Cohor. Alzheimer’s & Dementia. 2023/12/01 2023;19(S15):e076809. doi:https://doi.org/10.1002/alz.076809
6. Suciu I, Delp J, Gutbier S, Suess J, Henschke L, Celardo I, Mayer TU, Amelio I, Leist M. Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors. Antioxidants. 2024; 13(1):49. https://doi.org/10.3390/antiox13010049
7. Biancotti JC, Espinosa-Jeffrey A. Metabolomic Profiling of the Secretome from Human Neural Stem Cells Flown into Space. Bioengineering. 2024; 11(1):11. https://doi.org/10.3390/bioengineering11010011
8. Kelly GJ, Sabeen AK, Celine S, et al. Vagal interoception of microbial metabolites from the small intestinal lumen. bioRxiv. 2023:2023.12.18.572257. doi:10.1101/2023.12.18.572257
9. Riviere-Cazaux C, Rajani K, Rahman M, et al. Methodological and analytical considerations for intra-operative microdialysis. Fluids and Barriers of the CNS. 2023/12/19 2023;20(1):94. doi:10.1186/s12987-023-00497-2

Aging

10. Fernando R, Shindyapina AV, Ost M, et al. Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging. Communications Biology. 2023/12/08 2023;6(1):1240. doi:10.1038/s42003-023-05595-3

Women’s Health & Diabetes

11. Van JAD, Luo Y, Danska JS, et al. Postpartum defects in inflammatory response after gestational diabetes precede progression to type 2 diabetes: a nested case-control study within the SWIFT study. Metabolism. 2023/12/01/ 2023;149:155695. doi:https://doi.org/10.1016/j.metabol.2023.155695

Microbiome

12. Wu Y, Peng L, Feng P, et al. Gut microbes consume host energy and reciprocally provide beneficial factors to sustain a symbiotic relationship with the host. Science of The Total Environment. 2023/12/15/ 2023;904:166773. doi:https://doi.org/10.1016/j.scitotenv.2023.166773
13. JanssenDuijghuijsen L, Looijesteijn E, van den Belt M, et al. Changes in gut microbiota and lactose intolerance symptoms before and after daily lactose supplementation in individuals with the lactase non-persistent genotype. The American Journal of Clinical Nutrition. 2023/12/28/ 2023;doi:https://doi.org/10.1016/j.ajcnut.2023.12.016

Infectious Disease

14. Chatelaine HAS, Chen Y, Braisted J, Chu SH, Chen Q, Stav M, Begum S, Diray-Arce J, Sanjak J, Huang M, et al. Nucleotide, Phospholipid, and Kynurenine Metabolites Are Robustly Associated with COVID-19 Severity and Time of Plasma Sample Collection in a Prospective Cohort Study. International Journal of Molecular Sciences. 2024; 25(1):346. https://doi.org/10.3390/ijms25010346
15. Shang W, Qian H, Zhang S, et al. Human blood metabolites and risk of sepsis: A Mendelian randomization investigation. European Journal of Clinical Investigation. 2023/12/02 2023;n/a(n/a):e14145. doi:https://doi.org/10.1111/eci.14145
16. Elgart M, Zhang Y, Zhang Y, et al. Anaerobic pathogens associated with OSA may contribute to pathophysiology via amino-acid depletion. EBioMedicine. 2023;98:104891. doi:10.1016/j.ebiom.2023.104891

Inflammation

17. Wang EHC, Barresi-Thornton R, Chen L-C, Senna MM, Liao I-C, Chen Y, Zheng Q, Bouez C. The Development of Human Ex Vivo Models of Inflammatory Skin Conditions. International Journal of Molecular Sciences. 2023; 24(24):17255. https://doi.org/10.3390/ijms242417255

Kidney

18. Clark AJ, Saade MC, Vemireddy V, et al. Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury. Kidney International. 2023/12/01/ 2023;104(6):1150-1163. doi:https://doi.org/10.1016/j.kint.2023.09.013

Nutrition

19. Dorrain Yanwen L, Theresia Handayani M, Nilanjana S, et al. Metabolic variation reflects dietary intake in a multi-ethnic Asian population. medRxiv. 2023:2023.12.04.23299350. doi:10.1101/2023.12.04.23299350 (Metabolon Active Collaboration)
20. Playdon MC, Tinker LF, Prentice RL, et al. Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake. The American Journal of Clinical Nutrition. 2023/12/29/ 2023;doi:https://doi.org/10.1016/j.ajcnut.2023.10.016
21. Liu E, Manji KP, Kirby MA, et al. Effects of Zinc Supplementation on Metabolomic Profiles in Tanzanian Infants: A Randomized Trial. J Nutr. Published online December 11, 2023. doi:10.1016/j.tjnut.2023.12.011

Oncology

22. Qin B, Vyas M, Moore SC, et al. Abstract B072: Reproducibility of plasma metabolome over 1 year in a population-based study of Black breast cancer survivors. Cancer Epidemiology, Biomarkers & Prevention. 2023;32(12_Supplement):B072-B072. doi:10.1158/1538-7755.DISP23-B072
23. Matthew KA, Getz KR, Jeon MS, Luo C, Luo J, Toriola AT. Associations of Vitamins and Related Cofactor Metabolites with Mammographic Breast Density in Premenopausal Women. The Journal of Nutrition. 2023/12/18/ 2023;doi:https://doi.org/10.1016/j.tjnut.2023.12.023

Other

24. Farage G, Zhao C, Choi HY, et al. Matrix Linear Models for connecting metabolite composition to individual characteristics. bioRxiv. 2023:2023.12.19.572450. doi:10.1101/2023.12.19.572450
25. Suraj P, Oleg B, Nora S, et al. SLC25A48 is a human mitochondrial choline transporter. medRxiv. 2023:2023.12.04.23299390. doi:10.1101/2023.12.04.23299390

Toxicology

26. Alewel DI, Rentschler KM, Jackson TW, et al. Serum metabolome and liver transcriptome reveal acrolein inhalation-induced sex-specific homeostatic dysfunction. Scientific Reports. 2023/12/01 2023;13(1):21179. doi:10.1038/s41598-023-48413-w