Press Releases

Syngenta Continues to Have Access to Leading Biochemical Profiling Technology

RESEARCH TRIANGLE PARK, N.C. (December 4, 2012)— Metabolon, Inc., the pioneering leader in metabolomics-driven biomarker discovery and analysis, announced today that it has renewed a multi-year agreement with Syngenta, a world leading global agribusiness. Through this agreement, Metabolon will continue to provide Syngenta  broad access to its biochemical profiling technology for use in agricultural applications. Financial terms of the agreement were not disclosed.
Metabolon has extensive experience in rapidly profiling the biochemistry of plants. This metabolomics-driven approach enables the identification of biomarkers useful for the development of a wide range of diagnostics and provides insight into complex biochemical processes.
 
“We are delighted to continue our partnership with Syngenta, a leader in seed biotechnology and crop protection products,” said John Ryals, Ph.D., President and Chief Executive Officer of Metabolon. “This agreement signifies not only the value our biochemical analysis and expertise brings to our collaborators, but also our commitment to helping our partners in pharmaceutical, biotechnology and consumer products sectors meet their own business objectives.”
 
“Metabolon brings us key information that helps facilitate decision-making in R&D for developing new products,” said Michiel van Lookeren Campagne, Head of Biotechnology at Syngenta. “As Syngenta works to bring new technology to the market for our customers, these insights are increasingly important.”
 
About Metabolon
Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industry’s leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolon’s expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 500 client studies and processed over 50,000 samples for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit www.metabolon.com or contact Matt Zaske at mzaske@metabolon.com or 919-595-2200.
 
 
Media Contact:
Mackenzie Mills
Account Director
SpecOps Communications
mackenzie@specopscomm.com
212-518-7721
@SpecOpsComm

Gains proprietary lipids technology platform and further opportunities for diagnostics, personalized medicine and commercial services

Research Triangle Park, N.C. (August 1, 2012) – Metabolon, Inc. announces the completion of its acquisition of Lipomics Technologies, Inc.  This transaction combines Metabolon’s world-leading metabolomics technology platform for commercial services and diagnostics with Lipomics’ world-leading TrueMass® Profiling lipids technology platform.
 
Lipomics’ laboratory facilities will remain at its headquarters in Sacramento, California while Metabolon’s headquarters and laboratories will remain in Research Triangle Park.  Steven M. Watkins, Ph.D., Lipomics’ founder, will join Metabolon’s executive team as chief technology officer.  Financial terms of the transaction were not disclosed.
 
Michael Milburn, Ph.D., chief scientific officer of Metabolon, stated, “Metabolon has pioneered metabolomics technology and is the largest provider of solutions globally to the pharmaceutical, healthcare, consumer products, nutrition and agricultural industries, as well as to hundreds of academic institutions. Lipomics is the leader in technology to analyze lipids, including metabolites of fatty acids, acylcarnitines, sterols, amino acids, bile acids and eicosanoids. Together we have an unprecedented suite of technologies and capabilities to benefit our expanding customer base. The combined technologies will deliver new and improved diagnostic products and personalized medicine solutions for unmet needs, particularly in metabolic disease and cancer.”
 
“For the past 10 years Lipomics has taken pride in providing the best technology and science for understanding the role of lipids in human disease, principally in metabolic diseases associated with obesity and the lipid remodeling aspects of cancer,” said Dr. Watkins. “The prospect of combining our approach with Metabolon’s global platform is extremely exciting. Integrating the technologies will provide a deep and coherent understanding of biological systems and allow us to produce unparalleled services and products for years to come.”
 
John Ryals, Ph.D., chief executive officer of Metabolon, expressed his support of the acquisition saying, “By combining Metabolon and Lipomics, we have created the undisputed technology leader in the emerging field of metabolomics. We have product offerings that span from global metabolomics to complex lipid analysis to targeted analysis of many different classes of molecules.  By combining our two companies, we have more than 140 employees and 450 clients, have completed 2,000 commercial projects and have 200 scientific papers either published or under review. We are not aware of another company or institution with this record of scientific and commercial achievement in the field of metabolomics.
 
“We are the leader in the commercialization of metabolomics with a profitable commercial life sciences service business and have launched the world’s first metabolomics-based diagnostic test for type 2 diabetes risk based on biomarkers that measure insulin resistance. We expect that in 2013 we will be marketing additional diagnostic products aimed at diseases related to obesity and cancer, and are committed to maintaining our position as the world’s leader in metabolomics.”
 
About Lipomics Technologies
Lipomics provides metabolite profiling, biomarker discovery and metabolism consultation services to industry and academia. Its quantitative profiling assays are used to develop an understanding of metabolism in disease, the effects of drugs or foods on metabolism and for identifying biomarkers for use in clinical trials and as commercial products. Lipomics’ expertise in lipid and intermediary metabolism drives its development of research and clinical assays. Its TrueMass® Profiling is a suite of analytical panels that provide comprehensive and quantitative coverage of key pathways involved in metabolic, cardiovascular and inflammatory conditions.
 
About Metabolon
Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industry’s leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolon’s expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 500 client studies and processed over 50,000 samples for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit www.metabolon.com or contact Matt Zaske at mzaske@metabolon.com or 919-595-2200.
 
Media Contact:
LHA
Mackenzie Mills
mmills@lhai.com
212-838-3777
@LHA_IR_PR

Clinical utility of Quantose™, the industry’s first metabolomics-driven diagnostic, to be highlighted in two poster presentations

RESEARCH TRIANGLE PARK, N.C. (July 16, 2012) – Metabolon, Inc., announced today that Quantose™, its new prediabetes blood test, will be featured at the 2012 AACC Clinical Lab Expo, being held July 17-19 in Los Angeles, CA. Two poster presentations at the Expo will demonstrate the test’s utility to detect patients at risk for diabetes, even within the healthy range of hemoglobin A1C. In addition, information on Quantose™ and on the firm’s expanding diagnostic portfolio will be available at the Metabolon booth (#1150). For Metabolon, a pioneer in the field of metabolomics, Quantose™ represents the first in a line of several new diagnostic products the company plans to bring market, including metabolomics-driven tests focused on metabolic disease and cancer.
 
Quantose™, the firm’s lead product, is a novel blood test for prediabetes that reflects insulin resistance. The test is based on three recently identified non-glycemic biomarkers and insulin, and detects progression to prediabetes earlier than traditional glycemic measures such a hemoglobin A1C. By reflecting insulin resistance, Quantose™ provides clinicians with a useful tool that goes beyond glycemic measures to stratify their patients based on risk for developing diabetes.

Two posters highlighting the clinical utility of Quantose™ will be presented at the Expo.

Quantose™: A Prediabetes Diagnostic That Correlates with Multiple Risk Factors for Metabolic and Cardiovascular Disease.

• The clinical utility of Quantose™ as a simple, practical measure of insulin resistance will be demonstrated in this poster session with data highlighting the correlations between Quantose™ and other known risk factors for type 2 diabetes and cardiovascular disease. The presentation will include the notable finding that Quantose™ detected a significant number of insulin resistant individuals within the normal range of hemoglobin A1C – further substantiating Quantose™ as a useful compliment to hemoglobin A1C in assessing  prediabetes. The poster (#B-46 – Endocrinology/Hormones) will be presented by Dr. Jeff Cobb at Poster Session B on Tuesday, July 17, from 2:00p.m.-4:30p.m.

Differences in Insulin Resistance Stratification Using HbA1c and Metabolic Markers Apha-hydroxybutyrate, Linoleoyl-GPC, and Oleate.

• This poster will highlight the results of a clinical study performed at the University of North Carolina, Chapel Hill comparing the Quantose™ metabolic markers to hemoglobin A1C for the ability to detect insulin resistance. Data to be presented include the finding that Quantose™ scores closely track worsening dysglycemia as defined by hemoglobin A1C, but that Quantose™ also identifies a substantial subset of patients as insulin resistant despite hemoglobin A1C values within the normal range (<5.7%). The poster (#C-91 – Mass Spectrometry Applications) will be presented by Dr. Steven Cotten at Poster Session C on Wednesday, July 18, from 10:30a.m.-12:30p.m.

 
About Metabolon
Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industry’s leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolon’s expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 500 client studies and processed over 50,000 samples for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit www.metabolon.com or contact Matt Zaske at mzaske@metabolon.com or 919-595-2200.
 
Media Contact:
LHA
Mackenzie Mills
mmills@lhai.com
212-838-3777
@LHA_IR_PR

RESEARCH TRIANGLE PARK, N.C. (July 10, 2012) — Metabolon, Inc., a diagnostics and services company offering the industry’s leading biochemical profiling technology, announced today that the Helmholtz Zentrum Muenchen, Research Center for Environmental Health (www.helmholtz-muenchen.de) in Neuherberg, Germany, has successfully completed Metabolon’s validation requirements. This collaboration brings Metabolon’s technology platform to Germany.

The Helmholtz Zentrum Muenchen-Metabolon Joint Metabolomics Laboratory has successfully passed a series of stringent quality control processes and reviews, and has officially begun operations. Validation of this lab follows closely behind Shanghai Jiao Tong University Lab in China, which received the Company’s validation last month. The Helmholtz Zentrum Muenchen validation will further expand Metabolon’s commercial sample processing scope and gives the Company an important entry into the European market. This comes after the publication of “Human Metabolic Individuality in Biomedical and Pharmaceutical Research” in the journal Nature in 2011, which was carried out by researchers at the Helmholtz Zentrum Muenchen, the Wellcome Trust/Sanger Centre, King’s College and Metabolon, Inc.

"This is Metabolon’s second successful joint lab launch and fully demonstrates the organization’s commitment to replicating our mass spectrometry process for the benefit of metabolomics research," stated Metabolon CEO John Ryals.

About Metabolon
Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industry’s leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolon’s expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 500 client studies and processed over 50,000 samples for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit www.metabolon.com or contact Matt Zaske at mzaske@metabolon.com or 919-595-2200.

About Helmholtz Zentrum Muenchen
The Helmholtz Zentrum Muenchen pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum Muenchen has about 2,000 staff members. Its headquarters is located in Neuherberg, north of Munich. It is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 31,000 staff members. The non-targeted metabolome analysis is lead by Jerzy Adamski and located at the Genome Analysis Center (http://www.helmholtz-muenchen.de/gac/home/index.html) of the Helmholtz Zentrum München.

Media Contact:
LHA
Mackenzie Mills
mmills@lhai.com
212-838-3777
@LHA_IR_PR

Clinical data demonstrate test’s effectiveness in stratifying prediabetic patients based on insulin resistance levels

RESEARCH TRIANGLE PARK, N.C. (June 11, 2012) — Metabolon, Inc. announces that the clinical utility of the Company’s lead diagnostic product Quantose™ IR will be featured in five poster presentations at the 72^nd Annual Scientific Sessions of the American Diabetes Association (ADA) being held June 8-12 in Philadelphia. Quantose IR is a fasting blood test to measure insulin resistance (IR). The test measures levels of three novel non-glycemic biomarkers and insulin to detect prediabetes earlier and with greater sensitivity than traditional glycemic markers such as glucose and Hemoglobin A1C.

“This marks our fourth consecutive ADA annual meeting and our expanded presence this year reflects our Company’s continued focus on developing diagnostic tests related to metabolic disease,” said John Ryals, President and CEO of Metabolon. “As insulin resistance is known to precede Type 2 diabetes by up to 10 years, Quantose IR offers clinicians a tool for identifying patients at greatest risk for disease progression long before glycemic markers show evidence of dysregulation. Clinicians seeking to intervene in this high-risk group will be provided unique pathophysiological insight helpful in tailoring treatments to individual patients. Our Quantose IR test also provides a useful therapeutic monitoring tool to complement traditional markers in gauging treatment effectiveness due to its non-glycemic markers tracking so closely with changing insulin sensitivity.”

The following five abstracts related to Metabolon’s ongoing research and development efforts associated with Quantose IR will be featured at the ADA meeting:

“Early metabolic markers of the development of dysglycemia and Type 2 diabetes and their physiological significance”

• Alpha-hydroxybutyrate (AHB) and linoleoyl-glycerophosphocholine (L-GPC) are described as novel circulatory markers of insulin resistance, with clinical outcome data demonstrating their predictive risk to prediabetes and Type 2 diabetes and response to intervention. Additional studies are presented that examine the Quantose IR biomarker’s physiological significance such as their bioactivity on insulin secretion. Abstract # 1600-P, to be presented by Dr. Walter Gall during the Monday, June 11^th 12-2pm poster session.

“Pioglitazone improves insulin sensitivity by modulating novel biomarkers in impaired glucose tolerance” (Audio poster tour)

• Top-ranking insulin sensitivity biomarkers are measured in the T2D prevention study ACT NOW. The purpose of the study was to describe the response of the novel Quantose IR metabolites and its algorithm IR signature to pioglitazone pharmacotherapy and provide context of these observations in a diabetes prevention clinical setting. Abstract # 1182-P, to be presented by Dr. Walter Gall during the Saturday, June 9^th 11:30am-1:30pm poster session and the Sunday, June 10^th 12-1pm guided audio tour.

“Metabolomic profile associated with hepatic insulin resistance in nondiabetic subjects: results from RISC study” (Audio poster tour)

• Quantose IR metabolites AHB and L-GPC are associated with hepatic insulin resistance, non-alcoholic fatty liver disease and NASH, further validating the clinical importance of measuring these novel biomarkers associated with IR-related disease outcomes. Abstract # 1791-P, to be presented by Dr. Amalia Gastadelli during the Monday, June 11^th 12-2pm poster session.

“Effect of aging and exercise on novel insulin sensitivity marker linoleoyl-glycerophosphocholine” (Audio poster tour)

• Lifestyle intervention study with sedentary IR subjects demonstrate the response of Quantose IR metabolites AHB and L-GPC to aerobic exercise and further show associations of L-GPC with aging. Abstract # 714-P, to be presented by Dr. Jose de Jesus Garduno Garcia during the Monday, June 11^th 12-2pm poster session and the Monday, June 11^th 1-2pm guided audio tour.

“Genetic variants associated with diabetes related circulating metabolite levels and their role in type 2 diabetes and insulin sensitivity” (Audio poster tour)

• Genome-wide association studies were carried out with the RISC and Botnia prospective studies to identify and validate associations of genes and metabolites related to glycine, the top-ranking amino acid related to insulin sensitivity and proximal to Quantose IR metabolite AHB biosynthesis. Abstract # 1526-P, to be presented by Dr. Weijia Xie during the Monday, June 11^th 12-2pm poster session.

About Metabolon
Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industry’s leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolon’s expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 1,500 client studies and processed over 50,000 samples and 400 projects for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit www.metabolon.com or contact Matt Zaske at mzaske@metabolon.com or 919-595-2200.

Media Contact:
LHA
Mackenzie Mills
mmills@lhai.com
212-838-3777
@LHA_IR_PR

RESEARCH TRIANGLE PARK, N.C. (May 10, 2012) — Metabolon, Inc., a diagnostics and services company offering the industry’s leading biochemical profiling technology, announced today that in collaboration with Shanghai Jiao Tong University (SJTU), Metabolon has successfully implemented its technology platform in China. The SJTU-Metabolon Joint Metabolomics Laboratory passed various stringent quality control processes and has officially started operation. This allows Metabolon to work with academic and industrial scientists within China or other Asian countries to perform biochemical profiling experiments with Metabolon’s technology.

“The successful launch of the joint lab is a vital step in bringing the science of metabolomics to a significant, untapped market,” states Metabolon CEO John Ryals. “Our partnership with Shanghai Jiao Tong University is a further proof of Metabolon’s efforts to bring personalized medicine and metabolic biomarker research to all parts of the world. We were able to completely replicate our complex mass spectrometry based methods in a remote location due to our highly engineered and quality controlled process. This will open up expansion possibilities for Metabolon to service previously difficult to access markets across the globe”.

About Metabolon

Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industry’s leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolon’s expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 450 client studies and processed over 50,000 samples for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit www.metabolon.com or contact Matt Zaske at mzaske@metabolon.com or 919-595-2200.

SJTU-Metabolon Joint Metabolomics Laboratory
Prof. Dabing Zhang
Rm. 104, Bldg 1, School of Life Sciences and Biotechnology
Shanghai Jiaotong University
800 Dongchuan Rd.
Shanghai, China 200240
sjtumetabolic@sjtu.edu.cn
http://ncmcg.sjtu.edu.cn/metabolomics

Media Contact:
LHA
Mackenzie Mills
mmills@lhai.com
212-838-3777

RESEARCH TRIANGLE PARK, N.C. (April 17, 2012) — Metabolon, Inc., a diagnostics and services company offering the industry’s leading biochemical profiling technology announces that Metabolon and Takeda Pharmaceutical Company Limited (TSE: 4502), a global pharmaceutical company, have formed a multiyear research alliance that will focus on discovering therapeutic targets and biomarkers.

Metabolon has developed a proprietary analytical platform and software for biomarker discovery using metabolomics to accelerate drug discovery and development by accurately measuring the spectrum of biochemical changes in biological samples, and mapping these changes to their corresponding metabolic pathways. Metabolon will apply its platform to discover and validate targets, and identify novel pharmacodynamic biomarkers for translation into the clinic.

Metabolon’s CEO John Ryals said, “We are excited about the prospect of collaborating with Takeda to accelerate its research programs. Metabolon has built a unique platform and has accumulated a vast amount of institutional knowledge in the field of metabolome analysis. We believe that integrating metabolomic profiling into Takeda’s R&D programs may lead to novel therapies and more informed decisions.

About Takeda Pharmaceutical Company Limited:
Located in Osaka, Japan, Takeda is a research-based global company with its main focus on pharmaceuticals. As the largest pharmaceutical company in Japan and one of the global leaders of the industry, Takeda is committed to strive towards better health for patients worldwide through leading innovation in medicine. Additional information about Takeda is available through its corporate website www.takeda.com.

About Metabolon
Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industry’s leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolon’s expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 350 client studies and processed over 50,000 samples for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit www.metabolon.com or contact Philippe Chemla at pchemla@metabolon.com or 919-572-1711.

Media Contact:
LHA
Mackenzie Mills
mmills@lhai.com
212-838-3777

RESEARCH TRIANGLE PARK, N.C. (April 10, 2012) — Metabolon, Inc., a diagnostics and services company offering the industry’s leading biochemical profiling technology, announces the launch of its Disease Metabolism Strategic Outsourcing Program.

Through this program, Metabolon’s partners will collaborate toward shared objectives such as identifying novel targets, establishing high resolution phenotypic screening platforms, elucidating drug mechanism of action, discovering and validating pharmacodynamic biomarkers for translation to the clinic and for patient stratification. Partners will have access to dedicated scientific, technical and IT staff at Metabolon, along with the company’s proprietary disease ontologies, as well as supporting visualization tools for the integration of metabolomics data with existing or data derived from such disciplines as genomics and proteomics.

John Ryals, Metabolon President and CEO, said, “We are excited to launch our Strategic Outsourcing Program as it represents a step change in the way the industry will think about and use metabolomics. This initiative results from years of research and development at Metabolon and has been requested by our industrial clients to fully exploit the potential of our platform. We believe that integrating metabolomic profiling deeply at the various stages of the R&D trajectory will lead to better targets, higher quality molecules, faster time to the clinic and reduced R&D risk and cost.”

Metabolon has completed hundreds of projects including those in oncology and metabolic disorders, and has acquired vast institutional knowledge of the metabolic pathways and targets that are involved in the onset of disease and its progression. This new program offers a turnkey metabolism center of excellence that provides pharmaceutical and biotech partners access to the most advanced metabolomics research platforms, which serve to enhance their drug discovery and development efficiency. Metabolon’s platform yields actionable insight into key disease metabolic processes, drug action, and patient response.

About Metabolon
Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industry’s leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolon’s expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 350 client studies and processed over 50,000 samples for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit www.metabolon.com or contact Philippe Chemla at pchemla@metabolon.com or 919-572-1711.

Media Contact:
LHA
Mackenzie Mills
mmills@lhai.com
212-838-3777

RESEARCH TRIANGLE PARK, N.C. (March 27, 2012) — Metabolon, Inc., a diagnostics and services company offering the industry’s leading biochemical profiling technology, announces the grant of US Patent 8,131,473 "Data Analysis Methods for Locating Entities of Interest within Large Multivariable Datasets." The patent was issued on March 6, 2012 and is the sixth technology patent and nineteenth patent overall awarded to Metabolon. The invention describes analysis methods and computational tools developed by Metabolon to quickly and accurately locate biochemicals, genes and proteins of interest in large multivariate data.

The use of genomics, proteomics and metabolomics to answer a variety of biological questions has increased dramatically over the last few years. These ‘omics sciences generate massive amounts of data, and sifting through that data to identify biologically significant changes is a major rate-limiting step. The patented method enables the researcher to process, analyze, and interpret data more efficiently. Through the implementation of these techniques, the relevant changes in transcripts, proteins and biochemicals in an experimental sample can be quickly and accurately identified. This enables the interpretation of the results, and facilitates the understanding of biological mechanisms and modes of action.

About Metabolon
Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industry’s leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolon’s expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 350 client studies and processed over 50,000 samples for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit www.metabolon.com or contact Matt Zaske at mzaske@metabolon.com or 919-595-2200.

Media Contact:
LHA
Mackenzie Mills
mmills@lhai.com
212-838-3777

RESEARCH TRIANGLE PARK, N.C. (February 29, 2012) — Metabolon, Inc., a diagnostics and services company offering the industry’s leading biochemical profiling technology, announces the publication of "Software Techniques for Enabling High-Throughput Analysis of Metabolomic Datasets" in the book Metabolomics, ISBN 978-953-51-0046, edited by Ute Roessner and published by the open-access publisher, InTech. The book chapter describes software and computational tools developed by Metabolon to quickly and accurately process, analyze and interpret metabolomics data in a high-throughput environment.

The use of metabolomics to answer a variety of biological questions has increased dramatically over the last few years. Metabolomics analysis requires accurate and sensitive instrumentation (LC/MS, GC/MS, NMR, CE, etc.) to generate high-quality data that can be easily and rapidly analyzed. While instrumentation holds a critical role, processing the massive amounts of data generated by a metabolomics experiment is a major rate-limiting step. Metabolon has developed a suite of software and computational tools that play an important and direct role in the ability to process, analyze, and interpret metabolomics data. Through the implementation of these techniques the biochemicals in an experimental sample can be quickly and accurately identified which enables biochemical interpretation of the results and facilitates the understanding of biological mechanisms and modes of action.

Copies of the chapter can be accessed through the InTech link: http://www.intechopen.com/articles/show/title/software-techniques-for-enabling-high-throughput-analysis-on-metabolomic-datasets

About Metabolon
Metabolon, Inc. has advanced the field of metabolomics by pioneering and patenting the industry’s leading biochemical biomarker discovery and profiling platform. It has developed the technology to quickly identify and measure all of the biochemicals in a biological sample through its proprietary global processing method. Through the generation and interpretation of data, this method provides a precise understanding of disease etiology and drug action, and advances personalized medicine beyond what genomics and other approaches can promise. Metabolon’s expertise is being embraced by a wide range of pharmaceutical, biotechnology, food and agricultural companies. Metabolytics, its biomarker discovery and analysis business, has completed over 350 client studies and processed over 50,000 samples for customers in 2011 alone. Building on its expertise in biochemistry understanding, Metabolon is also developing proprietary diagnostic tests to determine and track disease progression. For more information about Metabolon, please visit www.metabolon.com or contact Matt Zaske at mzaske@metabolon.com or 919-595-2200.

Media Contact:
LHA
Mackenzie Mills
mmills@lhai.com
212-838-3777