Metabolon and Colgate Identify early Biomarkers in Periodontal Disease


Metabolon and Colgate Identify early Biomarkers in Periodontal Disease

RESEARCH TRIANGLE PARK, N.C. (September 22, 2010)—Metabolon, Inc., leaders in global metabolomics, biomarker discovery and biochemical analysis, announces the publication of “Assessment of Dentifrice on Periodontal Disease Biomarkers in Gingival Crevicular Fluid”, in the Journal of Periodontology (2010, Vol. 81, No. 9, Pages 1273-1279). The article reports the results of a biomarker validation study carried out in collaboration with co-authors Virginia M. Barnes and colleagues of Colgate-Palmolive, a global leader in oral care. Periodontal disease, described as inflammation of the gums, is among the most common infectious diseases. Triclosan, the active ingredient in Colgate Total (CT), is a proven therapeutic agent against gingivitis. CT is the only FDA approved dentifrice for the treatment of gingivitis.

The study follows previous research by Dr. Barnes and collaborators at Colgate-Palmolive Company which used Metabolon’s patented global metabolomic profiling platform to identify candidate biomarkers in gingival crevicular fluid samples from subjects with chronic periodontitis. In this latest report, the biomarkers associated with gingivitis and periodontitis identified in the previous study, were validated as sensitive indicators for periodontal diseases. The levels of inosine, lysine, putrescine and xanthine correlated with the therapeutic effects of brushing with CT, a triclosan-containing dentrifice, against gingivitis and provided biochemical confirmation that CT can provide therapeutic improvement against gingivitis. These four biomarkers were significantly altered before observable clinical changes suggesting they could be useful for rapidly assessing clinical efficacy of anti-gingivitis products.

Copies of the paper can be accessed through the Journal of Periodontology at:

About Metabolon
Metabolon is a diagnostics and services company offering the industry’s leading biochemical profiling platform. Metabolon’s patented platform provides a global analysis of complex biological samples for the discovery of markers and pathways associated with drug action and disease. This metabolomics-driven approach enables the identification of biomarkers useful for the development of a wide range of diagnostics and provides insight into complex biochemical processes such as drug action, toxicology and bioprocess optimization. For more information about Metabolon, please visit or contact Matt Zaske at (919) 595-2200.