Welcome to the Metabolon Blog!

We post commentary on all things metabolomics – from the latest publications to precision medicine. There are many exciting and growing metabolomics applications, so you never know what will inspire us to start writing. We invite you to subscribe and get each new post directly delivered to your inbox.

The 4Cs of Metabolomics

Dec 4, 2019, 12:02 PM
Metabolon provides unmatched depth and breadth of metabolomics insights because no other organization has the 4 essential capabilities upon which truly insight-deriving metabolomics depends: Coverage, Competency, Comparability and Capacity.
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Metabolomics Brings New Insights to Type 2 Diabetes Research

Nov 18, 2019, 9:03 AM
Metabolon scientists are hard at work searching for new insights to aid in understanding mechanisms contributing to the development of Type 2 diabetes (T2D) .
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Adding Metabolomics to Genomics to tackle challenges in Lung Cancer

Nov 13, 2019, 7:15 AM
The field of lung cancer research has experienced many breakthroughs in recent years, particularly in precision medicine where oncologists can match genetic mutations to targeted therapies. However, many perplexing questions remain. Why does cancer impact some people and not others? Why do some people respond well to treatments and others don’t? For all the progress, we still have a long way to go.
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Microbiome Metabolism Reveals Mysteries of Diet’s Link to Epilepsy

Nov 6, 2019, 6:09 AM
Human health is complex, and the influence each internal system has on another can be quite extensive. Take epilepsy, for instance. It is well-established that a low-carbohydrate, high-fat ketogenic diet (KD) can help treat refractory epilepsy, which affects more than a third of epileptic patients who don’t respond to existing anticonvulsive drugs. What scientists haven’t understood until recently is how this kind of diet translates to brain activity. Turns out the answer lies in the gut microbiome.
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Q&A: Approach to frailty population health study with Brent Richards, M.D., M.Sc., Faculty of Medicine at McGill University

Sep 16, 2019, 6:14 AM
We sat down with Brent Richards, M.D., M.Sc., from the Faculty of Medicine at McGill University, to discuss the Canadian population health collaborative study that is aimed at discovering key frailty biomarkers to shed light on why some people become frail, determine the severity of frailty and what can be done to help avoid the condition.
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The skin microbiome: how metabolomics can advance the next frontier in skin health

Aug 26, 2019, 5:48 AM
What about the microbiome of other body locations, particularly our largest organ – the skin?
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There is Truth to the Adage “Get Your Beauty Rest”

Aug 6, 2019, 11:41 AM
The fountain of youth is what most people desire as they begin to notice faint lines of wisdom. Factors from a person’s biology or genetics to their environment and lifestyle, including sleep habits, alter metabolite levels affecting the health and appearance of skin. These mechanisms lead to the aging process long before we see the impact on our skin.
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Obesity – A Massive Problem Impacted by Tiny Things

Jul 22, 2019, 11:25 AM
The prevalence of obesity has increased at a breathtaking rate over the last few decades, with nearly half of the global population estimated to be overweight. This staggering ratio represents a tremendous disease burden since obesity is a major risk factor for many comorbidities, such as cardiovascular disease, fatty liver, and type 2 diabetes. Challenging solutions to address the rise in obesity are complex and not readily isolated to a small collection of genes.
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Charting a Path to Chronotherapy: An Atlas of Circadian Metabolism

Oct 23, 2018, 3:04 PM
A circadian rhythm is any biological process driven by endogenous cellular clocks that follows an oscillation of about 24 hours. Disruptions in circadian rhythms resulting from our modern lifestyle are associated with familiar afflictions ranging from jet lag to mood and sleep disorders.
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Metabolomics Approaches for NASH and NAFLD R&D

Sep 10, 2018, 8:11 AM
Metabolomics gives us valuable methods to compare preclinical model trials to human models of NASH. In this post, we share a case study with Gilead Sciences. More study is needed, but metabolomics may one day prove to outperform more invasive methods of assessing liver fibrosis, revealing opportunities to incorporate metabolomics into diagnostic tools.
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The Road Less Traveled: The Faster Path to Biological Insights

Jul 9, 2018, 10:30 AM
Researchers continue to mine the genome for clues that assist in understanding susceptibility to disease, selection of targets for combating disease, and the biomarkers indicating response. Surprisingly, though, a fast and valuable source of data that can either lead or strengthen this pursuit is not always part of the equation.
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Research shows that acetaminophen has unexpected effects on regulation of sex hormones

Apr 16, 2018, 10:00 AM
A new study showed the potentially negative impact of the widely used, over-the-counter drug acetaminophen (paracetamol) on sex hormones, which has significant implications for reproductive health. It also highlights the power of genomic and metabolomic profiling to better understand drug mechanisms of action and metabolism even in common drugs such as acetaminophen.
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Why do some people respond to cancer therapy while others do not?

Feb 28, 2018, 8:00 AM
Why do some people respond to a cancer therapy and some do not? While cancer is a genetic disease, response to therapy is not as systematic or clear-cut as simply matching a mutation to treatment. Other factors are clearly involved. Recent work in both mice and humans suggests that one answer may involve the microbiome.
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PART 3 | A case study in metabolomics for inherited metabolic disorders - GLUT1 Deficiency Syndrome

Jan 8, 2018, 9:20 AM
In this final blog post of our 3-part series on clinical metabolomics, we summarize a recent paper that highlights how metabolomics can be used to identify novel metabolic abnormalities and potential biomarkers associated with an inherited metabolic disorder called GLUT 1 deficiency syndrome (GLUT1-DS). The study is the first to investigate metabolomics perturbation in GLUT1-DS patients, as well as treatment of the disorder with a ketogenic diet (KD), which is currently the only treatment available.
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Part 2 | Improving Rare Disease Detection with Clinical Metabolomics

Dec 18, 2017, 10:05 AM
In this second part of our 3-part series on clinical metabolomics and its applications, we discuss how rare diseases, namely inherited metabolic disorders, can be screened using the technology.
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