Metabolon Discover
Liver Fibrosis Discovery Panel
Unrivaled metabolic phenotyping
Rigorous quality control
Revolutionary data visualization
About Liver Fibrosis Discovery Panel
Effective prognosis and treatment of liver disease depends on the extent of liver damage and fibrosis. Improving prognosis requires finding early and intermediate markers of liver fibrosis. Since liver pathogenesis is closely linked to metabolic dysfunction, metabolites can be leveraged as biomarkers for liver fibrosis. The current biomarkers of liver fibrosis are limited by their lack of specificity to predict etiology and lack of sensitivity to distinguish intermediate stages.
The Liver Fibrosis Discovery Panel will provide deeper insights for researchers and thereby help them address key factors in liver fibrosis, including mechanistic insights, personalized medicine, and drug discovery, and testing. This panel covers diverse biological pathways that contribute to liver fibrosis and will provide higher confidence in identifying markers that lead to fibrosis.
Liver Fibrosis Discovery Panel Details
The Liver Fibrosis Discovery Panel analyzes 105 metabolites associated with the initiation and progression of liver fibrosis. To view more details about the metabolite list, download the technical sheet.
| Sample Type and Required Amounts | |
|---|---|
| Sample Type | Sample Requirements |
| Mammalian Plasma/Serum | 200 µL |
| Liver Tissue | 50 to 100 mg |
Disclaimer: This method is for Research Use Only and is not to be used for diagnostic purposes.
Unrivaled Metabolic Phenotyping
Untargeted metabolomics can help researchers understand what is present in any biological sample, but accurate detection, identification, and ultimately, quantification of analytes can vary greatly based on sample type, sample preparation, instrumentation, methodology, and data analysis capabilities. All Metabolon Discover services leverage Metabolon’s proprietary LC-MS metabolomics platform and integrated bioinformatics solution, giving you industry-leading resolution and reproducible sample analyses, all referenced against the world’s largest level 1 metabolomics compound library.
Delivering Absolute Quantification for Research and Biomarker Analysis
Our readily available or custom developed quantitative assays help you achieve your research and biomarker validation objectives with precise and fully validated methods. Our targeted assays and panels cover >1,000 metabolites and lipids across a wide range of biochemical classes, metabolic pathways, and physiological processes, and they can be customized to best fit any application.
Data Analysis Tools
Results of your metabolomic analysis using the Liver Fibrosis Discovery Panel are delivered in the MyMetabolon portal. The portal offers revolutionary data analysis tools to help you visualize and identify metabolites of significance within your sample and the impact of those metabolites on your pathways of interest.
The Discovery Panel Report
Within the Discovery Panel Report, you can visualize all detected metabolites in a bubble plot. You can select statistical comparisons, adjust the p-value, flip the fold change, and search for a metabolite of interest from the toolbar at the top. You can also explore the significantly up- and- down-regulated metabolites. Within the bubble plot, you can quickly identify metabolites of significance and click those metabolites to learn more. You can also download an image of the bubble plot repurposed for redistribution outside the MyMetabolon portal.
Impact Explorer
Impact Explorer is the next step in diving deeper into your Discovery Panel data. Select up to six statistical comparisons to view within the heliogram visualization, which is a reimagining of a heatmap of metabolite fold changes grouped by pathway and organized in a circular view. You can click on specific metabolites or associations and view the relationship between the groups. Additionally, you can download an image file for any view you find interesting in the heliogram.
Metabolite Profile Finder
The Metabolite Profile Finder can be used to explore a specific metabolite or pathway of interest. Both can be accessed by clicking the Profile Finder tab, or by navigating from the Discovery Panel Report tab. In the Metabolite Profile Finder, you can see an overview of the metabolite of interest. This page includes links to PubChem, KEGG, and HMDB for further education. You can also view how that metabolite was statistically represented in each of the study comparisons. Finally, you can see the associations linked to a given metabolite.
Applications for the Liver Fibrosis Discovery Panel
Nutrition
Metabolomics can be essential for investigating the association between nutrition and health status, as metabolites represent a functional readout of the interface between diet and the complex metabolic systems that influence both health and disease. By reporting the interactions of metabolites within defined pathways, targeted metabolomics can help investigators gain new insights into the absorption and digestion of diet-derived macronutrients, monitor metabolism of various organ systems, and subsequently assess the underlying biology of multiple health and disease states.
Cardiovascular Disease
Heart failure is a leading cause of death worldwide, and there are numerous factors that lead to this and other cardiovascular diseases (CVDs). Metabolomics can illuminate CVD at multiple levels. In preclinical studies that used cardiomyocytes or heart tissue from model organisms, metabolomics advanced our understanding of mitochondrial function, energetics, and redox status and thereby drove critical insights into disease mechanisms. In human studies, metabolomics offers the opportunity to account for well-established CVD risk factors such as cholesterol and complex lipids, while simultaneously profiling thousands of other biochemicals in an unbiased fashion to enable the discovery of novel disease mechanisms and biomarkers.
Diabetes
According to the most recent report from the Centers for Disease Control diabetes is a serious metabolic condition affecting more than 37 million Americans and 460 million people worldwide. Despite being a worldwide epidemic, much remains unknown about individual risk factors for developing diabetes, and research is currently underway to identify new and effective treatments for diabetes at all stages. By facilitating the assessment of specific metabolic pathways impacted by diabetes, targeted metabolomics can be a critical tool for identifying biomarkers of disease onset for early intervention and novel targets to control disease progression, and for the development of new pharmaceuticals with specific mechanisms of action.
Oncology
Dysregulated metabolism contributes to but is not essential for the growth and proliferation of individual cancer cells — patient physiology is as much a part of the equation as the tumor. Metabolomics can both identify cancer-specific drug targets and assess the patient’s phenotype more broadly. The information revealed in metabolomics data can then, address key questions like ‘who will respond to the therapy?’, ‘How can we expand the pool of responders?’, or ‘How can we predict adverse events?’ By providing a functional readout of the molecular phenotype, metabolomics informs decision-making and positions development programs for success.
Big Insights with Metabolon
Cited in over 3,000 publications, we help scientists and manufacturers gain greater insight into their studies through metabolomics. See how our approach can become a successful part of your workflow.
Contact Us
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Request a quote for our services, get more information on sample types and handling procedures, request a letter of support, or submit a question about how metabolomics can advance your research.
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