Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia
Author: Stewart, Amy E.; Zachman, Derek K.; Castellano-Escuder, Pol; Kelly, Lois M.; Zolyomi, Ben; Aiduk, Michael D. I.; Delaney, Christopher D.; Lock, Ian C.; Bosc, Claudie; Bradley, John; Killarney, Shane T.; Stuart, J. Darren; Grimsrud, Paul A.; Ilkayeva, Olga R.; Newgard, Christopher B.; Chandel, Navdeep S.; Puissant, Alexandre; Wood, Kris C.; Hirschey, Matthew D.
Year Published: 2025
Media Outlet: Nature Metabolism
Open Access? No
Matrix: Non-Microbial Cell
Biological Themes: Cell proliferation and cell cycle, Vascular function
Product(s): Global Discovery Panel
Cited in over 3,000 publications, we help scientists and manufacturers gain greater insight into their studies through metabolomics.
GET STARTED
Talk with an expert
Request a quote, get detailed information on sample types, or learn how metabolomics can accelerate your research. Find our contact details are here.
Find us on:
