Integrated screens reveal that guanine nucleotide depletion, which is irreversible via targeting IMPDH2, inhibits pancreatic cancer and potentiates KRAS inhibition
Author: Wu, Di; Zhu, Chunbin; Pan, Haoqi; Xu, He; Xu, Jin; Liu, Yang; Wang, Sikai; Xiao, Mingming; Yu, Xianjun; Shi, Si
Year Published: 2026
Media Outlet: Gut
Open Access? No
Matrix: Non-Microbial Cell
Biological Themes: Cell proliferation and cell cycle, Endocrine function, Pancreatic function
Product(s): Global Discovery Panel
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