LIVE WEBINAR
Live: Designing Microbiome Studies to Uncover Host and Microbial Metabolites Associated with Energy Balance
Gut microbiome research is illuminating the intricate role of microbial communities in weight regulation, offering insights that redefine our understanding of obesity and metabolic health. Studies have revealed that the composition and function of the gut microbiota can influence energy extraction from the diet, regulate appetite and satiety signals, and modulate inflammation and metabolism.
Metabolomics can characterize the metabolites present in the gut and provide insights into the function of the microbiome and how it affects the host’s metabolism. It enables scientists to identify unique metabolic signatures associated with specific gut microbiota compositions. By analyzing the metabolites present in the gut, researchers can gain insights into the metabolic activities of different microbial communities.
In this webinar, Karen Corbin, Ph.D., R.D., Associate Investigator at AdventHealth Translational Research Institute in Orlando, Florida, will discuss her research on the gut microbiome and its impact on health and metabolism and how she used both targeted and untargeted metabolomics to better understand how the gut microbiome contributed to human energy balance. Dr. Corbin will outline her methodology, including the study design and metabolomics analyses, and detail topline results of her research.
You will learn:
- How the gut microbiome impacts obesity and energy balance.
- Key methodological considerations for study design and analyses
- Benefits of targeted and untargeted metabolomics approaches
- Considerations for advancing the field of gut microbiome research
Program
There are complex interactions between host, diet, and the gut microbiome that impact health and metabolism. Obesity is a disease that at its foundation is driven by positive energy balance. We used a combination of targeted and untargeted metabolomics to better understand how the gut microbiome contributed to human energy balance. We implemented a randomized crossover-controlled feeding study where all assessments were done while study participants were housed in our metabolic ward. We deeply phenotyped both host and microbes. We uncovered that there is a diet-dependent relationship between the gut microbiome and human energy balance that can be characterized, in part, by host and microbial metabolites.
This section of the webinar will include:
- A brief introduction to the relationship between the gut microbiome and obesity/energy balance.
- A brief description of methodology- study design and metabolomics analyses
- Topline results connecting the gut microbiome and energy balance
Achieving fast, accurate, and reproducible metabolomic data can be a challenging task that requires investing in people, technology, and novel methods to derive functional insights. In this short session, we will demonstrate how Metabolon’s metabolomics-as-a-service solution can be l
- Results of the metabolomics analysis and how they expanded our understanding of the interactions between diet, host, and the gut microbiome.
- Key methodological considerations
- Future directions to advance the field
