Research Areas
Metabolomics is rapidly gaining adoption in drug development, largely due to its ability to discover and validate biomarkers that can help support key decisions throughout the process, from discovery through clinical trials.
Metabolomics incorporates all elements of a biological system, capturing the phenotypic output resulting from biologic and environmental interactions: the metabolome. Metabolomics is a powerful tool for addressing several challenges in translational research, from linking genome to phenome to optimizing drug development and predicting disease outcomes.
Metabolon’s unparalleled proprietary small molecule database and comprehensive team of experts is uniquely positioned to support your drug development journey from discovery to commercialization.
Metabolomics reflects biochemical activity within cells—and therefore more accurately represents the system’s functional status during treatment. It integrates many other sources of data, such as clinical measurements and genomics, providing a deeper insight than can be achieved without metabolomics. As the definitive representative of a phenotype, it is the final piece of multi-omics—and is key to systems biology.
Metabolomics can help clarify your MoA faster by providing deep and unparalleled insights
“Given the critical role of metabolic reprogramming, it is not surprising that targeting metabolism is now an active area of antifibrotic drug discovery…. We found that IM156 had profound metabolic effects and robust antifibrotic activity in the [murine] lung at plasma exposures that are clinically relevant and were well tolerated in humans.”
WILLETTE ET AL. 2021
Metabolomics can clarify ambiguities by letting you see the effect your drug has on a patient:
Metabolomics can help build confidence in the predictability of your model:
Metabolomics can add invaluable insight to your other data streams:
Once you see the full value of metabolomics, the only remaining question is: who does it best? While many laboratories have metabolite profiling or analytical chemistry capabilities, comprehensive metabolomics technologies are extremely rare.
Accurate, unbiased metabolite identification across the entire metabolome introduces signal-to-noise challenges that very few labs are equipped to handle. Also, translating massive quantities of data into actionable information is slow, if not impossible, for most because proper interpretation takes two things that are in short supply: experience and a comprehensive database.
Using our robust platform and visualization tools, our experts are uniquely able to tell you more about your molecule and develop assay panels to help you zero in on the results you need.
Coverage
Ability to interrogate thousands of metabolites across diverse biochemical space, revealing new insights and opportunities
Comparability
Ability to integrate the data from different studies into the same dataset, in different geographies, among different patients over time
Competency
Ability to inform on proper study design, generate high‐quality data, derive biological insights, and make actionable recommendations
Capacity
Ability to process hundreds of thousands of samples quickly and cost‐efficiently to service rapidly growing demand
Request a quote for our services, get more information on sample types and handling procedures, request a letter of support, or submit a question about how metabolomics can advance your research.
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