Event | 6th Microbiome R&D & Business Collaboration Forum
3rd Probiotics Congress
Skin Microbiome & Cosmeceuticals Congress
May 20, 2019 – May 22, 2019
Rotterdam, The Netherlands
Visit us at booth 8!
May 21, 2019 at 10:00 AM
Annie Evans, Ph.D., Director of Research and Development
Untargeted Metabolomics in Feces, a Functional Readout of Gut Microbial Activity
There is an established link between microbiome composition and host phenotype. Microbiome sequencing efforts capture the composition of the microbial species, but do not provide the mechanism by which those microbes affect the host. The analysis of fecal material using untargeted metabolomics provides that link, as it can identify the metabolites that mediate the host microbe interaction. An overview of untargeted metabolomics technology and two recent studies that combined metagenomic sequencing with untargeted metabolomics will be highlighted: first, a study which identified biomarkers for patient responders to checkpoint inhibitor therapy in metastatic melanoma patients and second, where a metabolite-based intervention strategy was identified which ameliorated post-dieting weight gain. These studies highlight the power of untargeted metabolomics to identify phenotype-mediating and actionable discoveries of microbial action.