Event │ Microbiome Movement – Drug Development Summit
June 26, 2019 – June 28, 2019
The Revere Boston Common Hotel, Boston, MA
Visit us at booth 7!
Annie Evans, Director, R&D, Metabolon, Inc.
Untargeted Metabolomics in Feces, a Functional Readout of Gut Microbial Activity
June 27, 2019 at 3:10 PM
There is an established link between microbiome composition and host phenotype. Microbiome sequencing efforts capture the composition of the microbial species, but do not provide the mechanism by which those microbes affect the host. The analysis of fecal material using untargeted metabolomics provides that link, as it can identify the metabolites that mediate the host microbe interaction. An overview of untargeted metabolomics technology and two recent studies that combined metagenomic sequencing with untargeted metabolomics will be highlighted: first, a study which identified biomarkers for patient responders to checkpoint inhibitor therapy in metastatic melanoma patients and second, where a metabolite-based intervention strategy was identified which ameliorated post-dieting weight gain. These studies highlight the power of untargeted metabolomics to identify phenotype-mediating and actionable discoveries of microbial action.