MEtabolon Blog
Welcome to the Metabolon Blog!
We post commentary on all things metabolomics – from the latest publications to precision medicine. There are many exciting and growing metabolomics applications, so you never know what will inspire us to start writing. We invite you to subscribe and get each new post directly delivered to your inbox.
Why do some people respond to cancer therapy while others do not?
Feb 28, 2018, 8:00 AM
Why do some people respond to a cancer therapy and some do not? While cancer is a genetic disease, response to therapy is not as systematic or clear-cut as simply matching a mutation to treatment. Other factors are clearly involved. Recent work in both mice and humans suggests that one answer may involve the microbiome.
PART 3 | A case study in metabolomics for inherited metabolic disorders - GLUT1 Deficiency Syndrome
Jan 8, 2018, 9:20 AM
In this final blog post of our 3-part series on clinical metabolomics, we summarize a recent paper that highlights how metabolomics can be used to identify novel metabolic abnormalities and potential biomarkers associated with an inherited metabolic disorder called GLUT 1 deficiency syndrome (GLUT1-DS). The study is the first to investigate metabolomics perturbation in GLUT1-DS patients, as well as treatment of the disorder with a ketogenic diet (KD), which is currently the only treatment available.
Part 2 | Improving Rare Disease Detection with Clinical Metabolomics
Dec 18, 2017, 10:05 AM
In this second part of our 3-part series on clinical metabolomics and its applications, we discuss how rare diseases, namely inherited metabolic disorders, can be screened using the technology.
PART 1 | Clinical metabolomics is just like basic research metabolomics – right?
Nov 30, 2017, 2:45 AM
We’re kicking off a 3-part series of blog posts to help explain what clinical metabolomics is, why it’s important and how it’s being applied in rare diseases, especially inherited metabolic disorders.
Does Population Health Hold Answers for Precision Medicine?
Oct 13, 2017, 7:00 AM
We live in a time of unprecedented good health in the western world – researchers, healthcare professionals, clinicians are all working together to help decrease illness, prevent disease, increase life span and improve quality of life. In the US, for example, the average lifespan for a man in 1950 was 65 years of age. By 2007, that number jumped to 75 years of age, and it is expected to continue increasing, which means a growing and aging population for many developed countries around the world.
Putting the ‘Gee!’ into the Genome: Metabolomics & Human Genomics Studies
Aug 21, 2017, 9:55 AM
You might think the title of this article is a little silly, but there is a good reason for excitement thanks to new insights from some recent studies that combined the power of genomics and metabolomics. What wows me is that when you couple information on genotype and molecular phenotype (aka metabolomics), you really get something special, not just for research but also for the clinic.
Metformin & Metabolism: Beyond Diabetes
May 29, 2017, 2:10 AM
Diabetes is the 21st century plague
You don’t want to get diabetes; you really don’t. Despite the fact that this disease is generally manageable, the consequences of losing the ability to regulate your blood sugar are potentially debilitating and even fatal. Complications of type 2 diabetes are many, and they can be extreme.
Go With Your Gut: Metabolomics & the Microbiome
May 4, 2017, 3:14 AM
While diet is thought to be one of the most important, variable determinants of an individual’s health, our overall health is also heavily influenced by the gut microbiome, a population of microorganisms living throughout an individual’s digestive system.
Metabolomics Needs Precision: The Case for Mass Spectrometry
Apr 17, 2017, 8:07 AM
Because of our long history with the science and technology of metabolomics, we’re often asked about the utility of various technologies. Here is our comparison of two popular metabolomics technology platforms - NMR versus LC-MS.
Nature, Nurture, Neutering & Nutrition: Metabolomic Insights into the Mysteries of Cat Metabolism
Mar 31, 2017, 8:19 AM
We asked David Allaway, PhD, Senior Research Scientist in Nutrition & Metabolism, to tell us about his recently published study and what he learned by working with Metabolon.
Oh my microbiome: why do you do this to me?
Feb 14, 2017, 7:38 AM
How many of us have gained weight in the past and decided that we did not like what we were seeing or perhaps that our weight was unhealthy? And, having seen our expanded waistlines, rear ends or what-have-yous, determined to do something about it? I have written recently about unhealthy weight gain and diabetes and what we might do about it.
Could Santa (or You) Be on the Path to Type 2 Diabetes?
Jan 12, 2017, 7:42 AM
Another year older, another year wiser, another Christmas has come and gone
Another year has passed. Another year older and perhaps another year wiser. We’ll see. At times like this we tend to look around us, take stock, and make grand New Year’s resolutions. Now that we’re a few weeks into 2017, how are yours holding up?
Diagnosing the Undiagnosed
Oct 14, 2016, 8:37 PM
Dr. Steve Watkins, Metabolon’s CTO, participated on the “The Future of Healthcare: Diagnosing the Undiagnosed” panel at last week’s Future in Review (FiRe) conference. In this video, he and panelists Dr. Katia Moritz, a clinical psychologist and documentary filmmaker, and Illumina’s Karen Possemato discuss the challenges and opportunities for patients and clinicians along an often-frustrating journey to find answers.
Exploring Human Metabolism to Map Genetic Influences
Oct 11, 2016, 8:57 AM
The metabolome describes all the small molecule metabolites in a single organism or biological sample and provides a snapshot of metabolic status at that particular moment. Combining the power of metabolomics with the genetic blueprint created by genome-wide association studies (GWAS) has allowed Metabolon and its collaborators to create an atlas of genetic influences on human blood metabolites.
Is Metabolomics the Rosetta Stone for Understanding the Microbiome?
Sep 7, 2016, 9:17 AM
There’s been a lot of interest recently in the microbiome and the “bugs” (bacteria) that live on and within us. Their breadth of influence on our health is astonishing – certainly in metabolic diseases such as diabetes, but also in disorders that aren’t so obvious, such as autism, chronic fatigue syndrome and depression.
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