MEtabolon Blog
Welcome to the Metabolon Blog!
We post commentary on all things metabolomics – from the latest publications to precision medicine. There are many exciting and growing metabolomics applications, so you never know what will inspire us to start writing. We invite you to subscribe and get each new post directly delivered to your inbox.
Diagnosing the Undiagnosed
Oct 14, 2016, 8:37 PM
Dr. Steve Watkins, Metabolon’s CTO, participated on the “The Future of Healthcare: Diagnosing the Undiagnosed” panel at last week’s Future in Review (FiRe) conference. In this video, he and panelists Dr. Katia Moritz, a clinical psychologist and documentary filmmaker, and Illumina’s Karen Possemato discuss the challenges and opportunities for patients and clinicians along an often-frustrating journey to find answers.
Exploring Human Metabolism to Map Genetic Influences
Oct 11, 2016, 8:57 AM
The metabolome describes all the small molecule metabolites in a single organism or biological sample and provides a snapshot of metabolic status at that particular moment. Combining the power of metabolomics with the genetic blueprint created by genome-wide association studies (GWAS) has allowed Metabolon and its collaborators to create an atlas of genetic influences on human blood metabolites.
Is Metabolomics the Rosetta Stone for Understanding the Microbiome?
Sep 7, 2016, 9:17 AM
There’s been a lot of interest recently in the microbiome and the “bugs” (bacteria) that live on and within us. Their breadth of influence on our health is astonishing – certainly in metabolic diseases such as diabetes, but also in disorders that aren’t so obvious, such as autism, chronic fatigue syndrome and depression.
The Key to Precision Medicine is a Blueprint of Individual Health
Jul 13, 2016, 9:32 AM
Precision medicine is at the heart of healthcare providers’ goals to improve health, diagnoses and treatment for their patients. The key to advancing precision medicine lies in first creating a blueprint of human health. This will require collecting and analyzing massive amounts of data to build an expansive toolbox of recommendations about wellness and treatment for individuals.
ASMS 2016: Round Up of Metabolon’s Presentations
Jun 14, 2016, 7:47 PM
The 64th American Society for Mass Spectrometry annual conference (ASMS) took place last week in San Antonio, TX. This meeting is always an important one for us.
We don’t study metabolism
Apr 26, 2016, 7:58 PM
I hear this curious, but understandable, refrain from time-to-time in response to suggesting that metabolomics could be a useful approach for advancing research. It suggests that the respondent does not view metabolic pathways as a general feature that defines biological function – which it is. That is, they don’t view it in the same way that they do pathways involving proteins and transcription factors.
Metabolomics in Nutrition & Exercise Science: An Interview with Dr. David Nieman
Mar 30, 2016, 8:08 PM
We asked David Nieman, D.Ph., FACSM, an expert in exercise science, to share his experience with metabolomics and how it has impacted his research.
Metabolic Individuality May Hold the Key to Precision Medicine
Feb 18, 2016, 7:16 PM
Despite human genome mapping and years of research, the hunt for genetic drivers of health and disease has been challenging. It is now clear that both genetic and environmental factors, such as the microbiome, diet, lifestyle, and chemical and drug exposure, influence human health and disease.
R-E-L-A-X. Successful metabolomics studies are not that hard
Jan 28, 2016, 7:21 PM
I like football (the American version that is), and I also like metabolomics. So, not surprisingly, as I was contemplating writing about how doing a successful metabolomics study is not really that difficult, these two topics collided.
The Cancer Metabolism Beachhead Expands with Metabolomics
Dec 9, 2015, 7:25 PM
The beat marches on for cancer metabolism with many compelling results and the entrance of molecules into clinical trials. While cancer metabolism is traditionally viewed as a reprogramming of energy metabolism and metabolic pathways that support cell replication and growth, many investigators are realizing that the metabolic processes that allow a tumor to initiate and thrive are even broader than this.
Is the Fountain of Youth a Metabolite Away?
Nov 10, 2015, 7:31 PM
The media touts a new stay-young regimen every day, such as caloric restriction (equal to starvation for a food lover like me) or the consumption of red wine (a more palatable undertaking). The truth is, aging is astoundingly complex and is influenced by our diet, environment, genetics and the microbiome within us.
Using Metabolomics to Reduce Drug Attrition in Pharma R and D
Oct 4, 2015, 8:49 PM
It’s well-known that the time and cost to bring a new pharmaceutical to market are considerable. The average length of time from target ID to a new therapeutic is about 13 years and costs roughly $1.5 billion, embedded within an overall failure rate of 95%. But why?
Metabolism: an old dog with new tricks
Sep 22, 2015, 8:52 PM
As research showing the intimate connection between metabolism (aka biochemistry) and higher-order cellular function mounts, I am simultaneously excited and puzzled. I get excited by new metabolism research and enthusiastically embrace the importance of it. But, I am often bewildered that, in this gene-centric world, not everyone gets as charged as I do.
Can Global Metabolonic Profiling be used as a Clinical Tool for Inborn Error of Metabolism Screening?
Sep 10, 2015, 8:56 PM
Global metabolomic profiling is a powerful tool for the discovery of diagnostic biomarkers. Recently, Metabolon has been involved with translational research to extend the application of metabolomics from population studies and biomarker discovery to individual patient testing (N-of-one studies) for the detection of inborn errors of metabolism (IEM).
What will it take to improve health assessment and realize precision medicine?
Aug 24, 2015, 8:58 PM
When most people think of precision medicine, genomics is top of mind. While genomics will play an undeniably important role in realizing precision medicine, most researchers recognize the need to include other types of phenotypic data in addition to medical history and standard clinical assessment.
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