Welcome to the Metabolon Blog!

We post commentary on all things metabolomics – from the latest publications to precision medicine. There are many exciting and growing metabolomics applications, so you never know what will inspire us to start writing. We invite you to subscribe and get each new post directly delivered to your inbox.

Metabolon reveals a new ally for drug research and development programs: Picking program winners and demonstrating their value

Dec 16, 2019, 12:23 PM
Today’s biopharma companies are faced with extreme competition to secure support from investors, approval from regulators and buy-in from payers. How can a company and its new molecule shine above the noise to overcome these challenges? Enter metabolomics, the study of metabolites, the small-molecule end products of metabolism collectively known as the metabolome.
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Tier 1 Metabolite Identifications: A Compass to Rich Research Insights

Dec 11, 2019, 10:53 AM
Research is like a treasure hunt. Without the right navigation tools, precious time is spent on trial and error exploration to find the right path, increasing the cost as well as the risk of program failure. Metabolomics provides uniquely valuable guidance for navigating a biological system, but the signal-to-noise ratio from vast amounts of data can cloud your ability to see the actionable insight.
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The 4Cs of Metabolomics

Dec 4, 2019, 12:02 PM
Metabolon provides unmatched depth and breadth of metabolomics insights because no other organization has the 4 essential capabilities upon which truly insight-deriving metabolomics depends: Coverage, Competency, Comparability and Capacity.
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Metabolomics Brings New Insights to Type 2 Diabetes Research

Nov 18, 2019, 9:03 AM
Metabolon scientists are hard at work searching for new insights to aid in understanding mechanisms contributing to the development of Type 2 diabetes (T2D) .
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Adding Metabolomics to Genomics to tackle challenges in Lung Cancer

Nov 13, 2019, 7:15 AM
The field of lung cancer research has experienced many breakthroughs in recent years, particularly in precision medicine where oncologists can match genetic mutations to targeted therapies. However, many perplexing questions remain. Why does cancer impact some people and not others? Why do some people respond well to treatments and others don’t? For all the progress, we still have a long way to go.
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Microbiome Metabolism Reveals Mysteries of Diet’s Link to Epilepsy

Nov 6, 2019, 6:09 AM
Human health is complex, and the influence each internal system has on another can be quite extensive. Take epilepsy, for instance. It is well-established that a low-carbohydrate, high-fat ketogenic diet (KD) can help treat refractory epilepsy, which affects more than a third of epileptic patients who don’t respond to existing anticonvulsive drugs. What scientists haven’t understood until recently is how this kind of diet translates to brain activity. Turns out the answer lies in the gut microbiome.
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An interview with the Founder and CEO of Siolta

Oct 21, 2019, 10:05 AM
We sat down for a conversation with Nikole Kimes, Ph.D., Co-Founder and CEO of Siolta. The company’s name, which is pronounced sheel-ta, is a Gaelic word for “seeds” and speaks to the company’s microbial therapeutics that are created to reseed the depleted gut microbiome with naturally occurring bacteria, which are essential for a healthy immune system.
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Small Molecules at the Intersection of Health and Microbiota

Oct 4, 2019, 11:24 AM
Metabolon Senior Study Director, Karen DeBalsi, Ph.D., will speak at the 5th Annual European Microbiome Congress. Her seminar titled, “Small Molecules at the Intersection of Health and Microbiota,” will explore how Metabolon’s approach to metabolomics can assess efficacy, monitor toxicity, provide discover biomarkers, measure therapeutic response, determine optimal dosing, gauge non-compliance, and segregate responders from non-responders. The following Q&A from Kiasko Research provides a preview of her upcoming presentation.
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Metabolomics: A Key to Realizing the Power of ‘Big Data’

Sep 28, 2019, 5:30 AM
Big data initiatives to understand individual health, disease, and therapeutic responses are underway using a wide range of 'omics and clinical assessment tools across a variety of large cohorts in population health studies.
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Q&A: Approach to frailty population health study with Brent Richards, M.D., M.Sc., Faculty of Medicine at McGill University

Sep 16, 2019, 6:14 AM
We sat down with Brent Richards, M.D., M.Sc., from the Faculty of Medicine at McGill University, to discuss the Canadian population health collaborative study that is aimed at discovering key frailty biomarkers to shed light on why some people become frail, determine the severity of frailty and what can be done to help avoid the condition.
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The skin microbiome: how metabolomics can advance the next frontier in skin health

Aug 26, 2019, 5:48 AM
What about the microbiome of other body locations, particularly our largest organ – the skin?
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There is Truth to the Adage “Get Your Beauty Rest”

Aug 6, 2019, 11:41 AM
The fountain of youth is what most people desire as they begin to notice faint lines of wisdom. Factors from a person’s biology or genetics to their environment and lifestyle, including sleep habits, alter metabolite levels affecting the health and appearance of skin. These mechanisms lead to the aging process long before we see the impact on our skin.
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Obesity – A Massive Problem Impacted by Tiny Things

Jul 22, 2019, 11:25 AM
The prevalence of obesity has increased at a breathtaking rate over the last few decades, with nearly half of the global population estimated to be overweight. This staggering ratio represents a tremendous disease burden since obesity is a major risk factor for many comorbidities, such as cardiovascular disease, fatty liver, and type 2 diabetes. Challenging solutions to address the rise in obesity are complex and not readily isolated to a small collection of genes.
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Charting a Path to Chronotherapy: An Atlas of Circadian Metabolism

Oct 23, 2018, 3:04 PM
A circadian rhythm is any biological process driven by endogenous cellular clocks that follows an oscillation of about 24 hours. Disruptions in circadian rhythms resulting from our modern lifestyle are associated with familiar afflictions ranging from jet lag to mood and sleep disorders.
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Metabolomics Approaches for NASH and NAFLD R&D

Sep 10, 2018, 8:11 AM
Metabolomics gives us valuable methods to compare preclinical model trials to human models of NASH. In this post, we share a case study with Gilead Sciences. More study is needed, but metabolomics may one day prove to outperform more invasive methods of assessing liver fibrosis, revealing opportunities to incorporate metabolomics into diagnostic tools.
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