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We post commentary on all things metabolomics – from the latest publications to precision medicine. There are many exciting and growing metabolomics applications, so you never know what will inspire us to start writing. We invite you to subscribe and get each new post directly delivered to your inbox.

Metabolomics Approaches for NASH and NAFLD R&D

Sep 10, 2018, 8:11 AM
Metabolomics gives us valuable methods to compare preclinical model trials to human models of NASH. In this post, we share a case study with Gilead Sciences. More study is needed, but metabolomics may one day prove to outperform more invasive methods of assessing liver fibrosis, revealing opportunities to incorporate metabolomics into diagnostic tools.
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The Road Less Traveled: The Faster Path to Biological Insights

Jul 9, 2018, 10:30 AM
Researchers continue to mine the genome for clues that assist in understanding susceptibility to disease, selection of targets for combating disease, and the biomarkers indicating response. Surprisingly, though, a fast and valuable source of data that can either lead or strengthen this pursuit is not always part of the equation.
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Why do some people respond to cancer therapy while others do not?

Feb 28, 2018, 8:00 AM
Why do some people respond to a cancer therapy and some do not? While cancer is a genetic disease, response to therapy is not as systematic or clear-cut as simply matching a mutation to treatment. Other factors are clearly involved. Recent work in both mice and humans suggests that one answer may involve the microbiome.
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PART 3 | A case study in metabolomics for inherited metabolic disorders - GLUT1 Deficiency Syndrome

Jan 8, 2018, 9:20 AM
In this final blog post of our 3-part series on clinical metabolomics, we summarize a recent paper that highlights how metabolomics can be used to identify novel metabolic abnormalities and potential biomarkers associated with an inherited metabolic disorder called GLUT 1 deficiency syndrome (GLUT1-DS). The study is the first to investigate metabolomics perturbation in GLUT1-DS patients, as well as treatment of the disorder with a ketogenic diet (KD), which is currently the only treatment available.
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Go With Your Gut: Metabolomics & the Microbiome

May 4, 2017, 3:14 AM
While diet is thought to be one of the most important, variable determinants of an individual’s health, our overall health is also heavily influenced by the gut microbiome, a population of microorganisms living throughout an individual’s digestive system.
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Oh my microbiome: why do you do this to me?

Feb 14, 2017, 7:38 AM
How many of us have gained weight in the past and decided that we did not like what we were seeing or perhaps that our weight was unhealthy? And, having seen our expanded waistlines, rear ends or what-have-yous, determined to do something about it? I have written recently about unhealthy weight gain and diabetes and what we might do about it.
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Exploring Human Metabolism to Map Genetic Influences

Oct 11, 2016, 8:57 AM
The metabolome describes all the small molecule metabolites in a single organism or biological sample and provides a snapshot of metabolic status at that particular moment. Combining the power of metabolomics with the genetic blueprint created by genome-wide association studies (GWAS) has allowed Metabolon and its collaborators to create an atlas of genetic influences on human blood metabolites.
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Is Metabolomics the Rosetta Stone for Understanding the Microbiome?

Sep 7, 2016, 9:17 AM
There’s been a lot of interest recently in the microbiome and the “bugs” (bacteria) that live on and within us. Their breadth of influence on our health is astonishing – certainly in metabolic diseases such as diabetes, but also in disorders that aren’t so obvious, such as autism, chronic fatigue syndrome and depression.
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ASMS 2016: Round Up of Metabolon’s Presentations

Jun 14, 2016, 7:47 PM
The 64th American Society for Mass Spectrometry annual conference (ASMS) took place last week in San Antonio, TX. This meeting is always an important one for us.
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We don’t study metabolism

Apr 26, 2016, 7:58 PM
I hear this curious, but understandable, refrain from time-to-time in response to suggesting that metabolomics could be a useful approach for advancing research. It suggests that the respondent does not view metabolic pathways as a general feature that defines biological function – which it is. That is, they don’t view it in the same way that they do pathways involving proteins and transcription factors.
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Metabolomics in Nutrition & Exercise Science: An Interview with Dr. David Nieman

Mar 30, 2016, 8:08 PM
We asked David Nieman, D.Ph., FACSM, an expert in exercise science, to share his experience with metabolomics and how it has impacted his research.
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