Dedicated to understanding difficult questions about human biology
Population health studies seek to address questions of aging and frailty, rare disease, vaccine response, nutrition and more, often using large cohorts of subjects. Population health studies often focus on human genomics, which can show the risk of disease. However, human genomics as a standalone can often leave unanswered questions about the manifestation of illness.
A multi-omics approach that includes metabolomics provides a complete picture of the entire physiology of a living being, including the biological system, enabling a deep understanding of health and disease, whether influenced by genes, the environment, epigenetics or the microbiome. The insights delivered from metabolomics can be extremely illuminating because they show the biochemical pathways that manifest as illness. By measuring changes in metabolite levels and mapping them to the appropriate biochemical pathways, researchers and clinicians can better understand health and the influences of genes, microbiome, environment and drug treatment. Metabolomics is fundamental to unlocking the genome and delivering on the promise of multi-omics.
At Metabolon, we know that the most informative population health studies integrate multiple biologic data points – including longitudinal molecular and phenotypic measurements, as well as individual genome sequences – to better define health or wellness for each person, predict disease transitions and target medical intervention. We anticipate that deep metabolic phenotyping of large national cohort programs will confidently identify fundamental factors in the development of major diseases, lead to the discovery of new biomarkers and reveal novel targets for clinical intervention.