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Microbiome

Now you can see how things work

Functional understanding of host and microbiome interactions guides the development of breakthrough therapeutic treatments.

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Stool Sample Collection: A Bottleneck to Gut Microbiome Research
Stop the guesswork with functional insight

Genomic sequencing can reveal microbiome richness and diversity – which and how many microbes are present – in a given microbiome, but cannot effectively measure what small molecule end products are bring produced, how they behave, or how they directly impact health. Global metabolomics provides the needed next level of understanding by revealing functional activity of microbes in a living system.

See beyond the gut

Metabolomics has the unique ability to detect microbial-derived biochemicals entering the bloodstream, crossing the gut-brain axis and interacting with other functional organs to inform on the microbiome’s role in influencing overall health.

See Our Skin Microbiome Solutions
Get the complete picture with a system-wide view

Metabolon’s global metabolomics platform provides a full view on host metabolism, xenobiotics, dietary metabolites and novel metabolites produced by the microbiome to guide which microbes and pathways to focus on for the desired therapeutic effect.

Leverage the power of focused quantification

Select from a series of targeted assay panels to measure effects on microbiome-related analytes with quantifiable and comparable data. Add to Metabolon’s global untargeted approach for the most comprehensive, precise and systematic view of microbiome related activity and actionable insights.

Study Design

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Related Resources

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OMNImet·GUT
6 July 2020

OMNImet·GUT

We’ve collaborated with DNA Genotek to deliver the first and only device designed for ambient-temperature storage and stabilization of human fecal samples for metabolomic analysis.
Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance
27 December 2019

Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance

Genetic research of elite athletic performance has been hindered by the complex phenotype and the relatively small effect size of the identified genetic variants. The aims of this study were to identify genetic predisposition to elite athletic performance by investigating genetically-influenced metabolites that discriminate elite athletes from non-elite athletes and to identify those associated with endurance sports. By conducting a genome wide association study with high-resolution metabolomics profiling in 490 elite athletes, common variant metabolic quantitative trait loci (mQTLs) were identified and compared with previously identified mQTLs in non-elite athletes. Among the identified mQTLs, those associated with endurance metabolites were determined. Two novel genetic loci in FOLH1 and VNN1 are reported in association with N-acetyl-aspartyl-glutamate and Linoleoyl ethanolamide, respectively. When focusing on endurance metabolites, one novel mQTL linking androstenediol (3alpha, 17alpha) monosulfate and SULT2A1 was identified. Potential interactions between the novel identified mQTLs and exercise are highlighted. This is the first report of common variant mQTLs linked to elite athletic performance and endurance sports with potential applications in biomarker discovery in elite athletic candidates, non-conventional anti-doping analytical approaches and therapeutic strategies.
Overcoming Challenges in Microbiome Research: A Panel Discussion
24 October 2019

Overcoming Challenges in Microbiome Research: A Panel Discussion

Watch to gain an understanding of how untargeted metabolomics can answer pressing questions in microbiome research.
Fish-oil supplementation in pregnancy, child metabolomics and asthma risk
1 August 2019

Fish-oil supplementation in pregnancy, child metabolomics and asthma risk

We recently demonstrated that maternal dietary supplementation with fish oil-derived n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) during pregnancy reduces the risk of asthma in the offspring but the mechanisms involved are unknown.
Physiological and Molecular Dissection of Daily Variance in Exercise Capacity
2 July 2019

Physiological and Molecular Dissection of Daily Variance in Exercise Capacity

Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity between the early and late part of their active phase. The daytime variance in mice was dependent on exercise intensity and relied on the circadian clock proteins PER1/2. High-throughput gene expression and metabolic profiling of skeletal muscle revealed metabolic pathways that are differently activated upon exercise in a daytime-dependent manner. Remarkably, we discovered that ZMP, an endogenous AMPK activator, is induced by exercise in a time-dependent manner to regulate key steps in glycolytic and fatty acid oxidation pathways and potentially enhance exercise capacity. Overall, we propose that time of day is a major modifier of exercise capacity and associated metabolic pathways.
Metabolomics – A Revolution in ‘Omics
8 March 2016

Metabolomics – A Revolution in ‘Omics

In this free eBook, you'll learn how mapping metabolites back to their key biochemical pathways helps identify biomakers and provides crucial insight into the function of genes, the basis of disease, and treatment effects. The sensitivity and versatility of metabolomics makes it an integral tool for a wide variety of research.
OMNImet·GUT

OMNImet·GUT

Microbiome, Nutrition, Population Health, Sample Preparation & Handling
Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance

Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance

Nutrition, Publications
Overcoming Challenges in Microbiome Research: A Panel Discussion

Overcoming Challenges in Microbiome Research: A Panel Discussion

Global Metabolomics, Immunology & Inflammation, Microbiome, Nutrition, Oncology, Personal Care & Cosmetics, Targeted Assays, Veterinary & Animal Health, Webinars
Fish-oil supplementation in pregnancy, child metabolomics and asthma risk

Fish-oil supplementation in pregnancy, child metabolomics and asthma risk

Nutrition, Publications
Physiological and Molecular Dissection of Daily Variance in Exercise Capacity

Physiological and Molecular Dissection of Daily Variance in Exercise Capacity

Nutrition, Publications
Metabolomics – A Revolution in ‘Omics

Metabolomics – A Revolution in ‘Omics

eBooks, Global Metabolomics, Infectious Disease, Microbiome, Multi-Omics Integration, Nutrition, Personal Care & Cosmetics, Targeted Assays

Metabolomics

  • About Metabolomics
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Solutions

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Insights

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Resources

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