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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Author: Mills, Evanna L.; Ryan, Dylan G.; Prag, Hiran A.; Dikovskaya, Dina; Menon, Deepthi; Zaslona, Zbigniew; Jedrychowski, Mark P.; Costa, Ana S. H.; Higgins, Maureen; Hams, Emily; Szpyt, John; Runtsch, Marah C.; King, Martin S.; McGouran, Joanna F.; Fischer, Roman; Kessler, Benedikt M.; McGettrick, Anne F.; Hughes, Mark M.; Carroll, Richard G.; Booty, Lee M.; Knatko, Elena V.; Meakin, Paul J.; Ashford, Michael L. J.; Modis, Louise K.; Brunori, Gino; Sévin, Daniel C.; Fallon, Padraic G.; Caldwell, Stuart T.; Kunji, Edmund R. S.; Chouchani, Edward T.; Frezza, Christian; Dinkova-Kostova, Albena T.; Hartley, Richard C.; Murphy, Michael P.; O’Neill, Luke A.
Year Published: 2018
Media Outlet: Nature

Open Access? No

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