Welcome to the Metabolon Blog!

We post commentary on all things metabolomics – from the latest publications to precision medicine. There are many exciting and growing metabolomics applications, so you never know what will inspire us to start writing. We invite you to subscribe and get each new post directly delivered to your inbox.

ASMS 2016: Round Up of Metabolon’s Presentations

Jun 15, 2016, 2:47 AM
The 64th American Society for Mass Spectrometry annual conference (ASMS) took place last week in San Antonio, TX. This meeting is always an important one for us.
Read more >

We don’t study metabolism

Apr 27, 2016, 2:58 AM
I hear this curious, but understandable, refrain from time-to-time in response to suggesting that metabolomics could be a useful approach for advancing research. It suggests that the respondent does not view metabolic pathways as a general feature that defines biological function – which it is. That is, they don’t view it in the same way that they do pathways involving proteins and transcription factors.
Read more >

Metabolomics in Nutrition & Exercise Science: An Interview with Dr. David Nieman

Mar 31, 2016, 3:08 AM
We asked David Nieman, D.Ph., FACSM, an expert in exercise science, to share his experience with metabolomics and how it has impacted his research.
Read more >

Metabolic Individuality May Hold the Key to Precision Medicine

Feb 19, 2016, 3:16 AM
Despite human genome mapping and years of research, the hunt for genetic drivers of health and disease has been challenging. It is now clear that both genetic and environmental factors, such as the microbiome, diet, lifestyle, and chemical and drug exposure, influence human health and disease.
Read more >

R-E-L-A-X. Successful metabolomics studies are not that hard

Jan 29, 2016, 3:21 AM
I like football (the American version that is), and I also like metabolomics. So, not surprisingly, as I was contemplating writing about how doing a successful metabolomics study is not really that difficult, these two topics collided.
Read more >

The Cancer Metabolism Beachhead Expands with Metabolomics

Dec 10, 2015, 3:25 AM
The beat marches on for cancer metabolism with many compelling results and the entrance of molecules into clinical trials. While cancer metabolism is traditionally viewed as a reprogramming of energy metabolism and metabolic pathways that support cell replication and growth, many investigators are realizing that the metabolic processes that allow a tumor to initiate and thrive are even broader than this.
Read more >

Is the Fountain of Youth a Metabolite Away?

Nov 11, 2015, 3:31 AM
The media touts a new stay-young regimen every day, such as caloric restriction (equal to starvation for a food lover like me) or the consumption of red wine (a more palatable undertaking). The truth is, aging is astoundingly complex and is influenced by our diet, environment, genetics and the microbiome within us.
Read more >

Using Metabolomics to Reduce Drug Attrition in Pharma R and D

Oct 5, 2015, 3:49 AM
It’s well-known that the time and cost to bring a new pharmaceutical to market are considerable. The average length of time from target ID to a new therapeutic is about 13 years and costs roughly $1.5 billion, embedded within an overall failure rate of 95%. But why?
Read more >

Metabolism: an old dog with new tricks

Sep 23, 2015, 3:52 AM
As research showing the intimate connection between metabolism (aka biochemistry) and higher-order cellular function mounts, I am simultaneously excited and puzzled. I get excited by new metabolism research and enthusiastically embrace the importance of it. But, I am often bewildered that, in this gene-centric world, not everyone gets as charged as I do.
Read more >

Can Global Metabolonic Profiling be used as a Clinical Tool for Inborn Error of Metabolism Screening?

Sep 11, 2015, 3:56 AM
Global metabolomic profiling is a powerful tool for the discovery of diagnostic biomarkers. Recently, Metabolon has been involved with translational research to extend the application of metabolomics from population studies and biomarker discovery to individual patient testing (N-of-one studies) for the detection of inborn errors of metabolism (IEM).
Read more >

What will it take to improve health assessment and realize precision medicine?

Aug 25, 2015, 3:58 AM
When most people think of precision medicine, genomics is top of mind. While genomics will play an undeniably important role in realizing precision medicine, most researchers recognize the need to include other types of phenotypic data in addition to medical history and standard clinical assessment.
Read more >

Biology’s “building inspector”

Jul 31, 2015, 4:01 AM
Continuing on the topic of my last post, I wanted to find an analogy that could paint a familiar, vivid picture of how metabolism relates to living systems and genetics and, therefore, why it’s an important research tool. The example a colleague and I came up with was that of a living organism being analogous to a house and the process by which they are constructed.
Read more >

Duh, it’s your biochemistry!

Jul 8, 2015, 4:04 AM
A lively discussion happened recently in a staff meeting on the need to raise awareness in the gene and protein world about how metabolism fits into their paradigm and why it’s important. The topic aroused a range of opinions, but on this day, one of my more enthusiastic colleagues proclaimed, “Duh, it’s your biochemistry!”
Read more >

NOTIFICATIONS

Get notified when new posts are published!

Required