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We post commentary on all things metabolomics – from the latest publications to precision medicine. There are many exciting and growing metabolomics applications, so you never know what will inspire us to start writing. We invite you to subscribe and get each new post directly delivered to your inbox.

PART 3 | A case study in metabolomics for inherited metabolic disorders - GLUT1 Deficiency Syndrome

Dec 4, 2017, 5:20 PM
In this final blog post of our 3-part series on clinical metabolomics, we summarize a recent paper that highlights how metabolomics can be used to identify novel metabolic abnormalities and potential biomarkers associated with an inherited metabolic disorder called GLUT 1 deficiency syndrome (GLUT1-DS). The study is the first to investigate metabolomics perturbation in GLUT1-DS patients, as well as treatment of the disorder with a ketogenic diet (KD), which is currently the only treatment available.
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We don’t study metabolism

Apr 27, 2016, 2:58 AM
I hear this curious, but understandable, refrain from time-to-time in response to suggesting that metabolomics could be a useful approach for advancing research. It suggests that the respondent does not view metabolic pathways as a general feature that defines biological function – which it is. That is, they don’t view it in the same way that they do pathways involving proteins and transcription factors.
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Metabolic Individuality May Hold the Key to Precision Medicine

Feb 19, 2016, 3:16 AM
Despite human genome mapping and years of research, the hunt for genetic drivers of health and disease has been challenging. It is now clear that both genetic and environmental factors, such as the microbiome, diet, lifestyle, and chemical and drug exposure, influence human health and disease.
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The Cancer Metabolism Beachhead Expands with Metabolomics

Dec 10, 2015, 3:25 AM
The beat marches on for cancer metabolism with many compelling results and the entrance of molecules into clinical trials. While cancer metabolism is traditionally viewed as a reprogramming of energy metabolism and metabolic pathways that support cell replication and growth, many investigators are realizing that the metabolic processes that allow a tumor to initiate and thrive are even broader than this.
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Is the Fountain of Youth a Metabolite Away?

Nov 11, 2015, 3:31 AM
The media touts a new stay-young regimen every day, such as caloric restriction (equal to starvation for a food lover like me) or the consumption of red wine (a more palatable undertaking). The truth is, aging is astoundingly complex and is influenced by our diet, environment, genetics and the microbiome within us.
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What will it take to improve health assessment and realize precision medicine?

Aug 25, 2015, 3:58 AM
When most people think of precision medicine, genomics is top of mind. While genomics will play an undeniably important role in realizing precision medicine, most researchers recognize the need to include other types of phenotypic data in addition to medical history and standard clinical assessment.
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