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We post commentary on all things metabolomics – from the latest publications to precision medicine. There are many exciting and growing metabolomics applications, so you never know what will inspire us to start writing. We invite you to subscribe and get each new post directly delivered to your inbox.

PART 3 | A case study in metabolomics for inherited metabolic disorders - GLUT1 Deficiency Syndrome

Dec 4, 2017, 5:20 PM
In this final blog post of our 3-part series on clinical metabolomics, we summarize a recent paper that highlights how metabolomics can be used to identify novel metabolic abnormalities and potential biomarkers associated with an inherited metabolic disorder called GLUT 1 deficiency syndrome (GLUT1-DS). The study is the first to investigate metabolomics perturbation in GLUT1-DS patients, as well as treatment of the disorder with a ketogenic diet (KD), which is currently the only treatment available.
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Part 2 | Improving Rare Disease Detection with Clinical Metabolomics

Nov 9, 2017, 6:05 PM
In this second part of our 3-part series on clinical metabolomics and its applications, we discuss how rare diseases, namely inherited metabolic disorders, can be screened using the technology.
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PART 1 | Clinical metabolomics is just like basic research metabolomics – right?

Nov 2, 2017, 9:45 AM
We’re kicking off a 3-part series of blog posts to help explain what clinical metabolomics is, why it’s important and how it’s being applied in rare diseases, especially inherited metabolic disorders.
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Does Population Health Hold Answers for Precision Medicine?

Oct 13, 2017, 2:00 PM
We live in a time of unprecedented good health in the western world – researchers, healthcare professionals, clinicians are all working together to help decrease illness, prevent disease, increase life span and improve quality of life. In the US, for example, the average lifespan for a man in 1950 was 65 years of age. By 2007, that number jumped to 75 years of age, and it is expected to continue increasing, which means a growing and aging population for many developed countries around the world.
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Go With Your Gut: Metabolomics & the Microbiome

May 4, 2017, 10:14 AM
While diet is thought to be one of the most important, variable determinants of an individual’s health, our overall health is also heavily influenced by the gut microbiome, a population of microorganisms living throughout an individual’s digestive system.
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Could Santa (or You) Be on the Path to Type 2 Diabetes?

Jan 12, 2017, 3:42 PM
Another year older, another year wiser, another Christmas has come and gone Another year has passed. Another year older and perhaps another year wiser. We’ll see. At times like this we tend to look around us, take stock, and make grand New Year’s resolutions. Now that we’re a few weeks into 2017, how are yours holding up?
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Diagnosing the Undiagnosed

Oct 15, 2016, 3:37 AM
Dr. Steve Watkins, Metabolon’s CTO, participated on the “The Future of Healthcare: Diagnosing the Undiagnosed” panel at last week’s Future in Review (FiRe) conference. In this video, he and panelists Dr. Katia Moritz, a clinical psychologist and documentary filmmaker, and Illumina’s Karen Possemato discuss the challenges and opportunities for patients and clinicians along an often-frustrating journey to find answers.
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Exploring Human Metabolism to Map Genetic Influences

Oct 11, 2016, 3:57 PM
The metabolome describes all the small molecule metabolites in a single organism or biological sample and provides a snapshot of metabolic status at that particular moment. Combining the power of metabolomics with the genetic blueprint created by genome-wide association studies (GWAS) has allowed Metabolon and its collaborators to create an atlas of genetic influences on human blood metabolites.
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Is Metabolomics the Rosetta Stone for Understanding the Microbiome?

Sep 7, 2016, 4:17 PM
There’s been a lot of interest recently in the microbiome and the “bugs” (bacteria) that live on and within us. Their breadth of influence on our health is astonishing – certainly in metabolic diseases such as diabetes, but also in disorders that aren’t so obvious, such as autism, chronic fatigue syndrome and depression.
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The Key to Precision Medicine is a Blueprint of Individual Health

Jul 13, 2016, 4:32 PM
Precision medicine is at the heart of healthcare providers’ goals to improve health, diagnoses and treatment for their patients. The key to advancing precision medicine lies in first creating a blueprint of human health. This will require collecting and analyzing massive amounts of data to build an expansive toolbox of recommendations about wellness and treatment for individuals.
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Metabolic Individuality May Hold the Key to Precision Medicine

Feb 19, 2016, 3:16 AM
Despite human genome mapping and years of research, the hunt for genetic drivers of health and disease has been challenging. It is now clear that both genetic and environmental factors, such as the microbiome, diet, lifestyle, and chemical and drug exposure, influence human health and disease.
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Can Global Metabolonic Profiling be used as a Clinical Tool for Inborn Error of Metabolism Screening?

Sep 11, 2015, 3:56 AM
Global metabolomic profiling is a powerful tool for the discovery of diagnostic biomarkers. Recently, Metabolon has been involved with translational research to extend the application of metabolomics from population studies and biomarker discovery to individual patient testing (N-of-one studies) for the detection of inborn errors of metabolism (IEM).
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What will it take to improve health assessment and realize precision medicine?

Aug 25, 2015, 3:58 AM
When most people think of precision medicine, genomics is top of mind. While genomics will play an undeniably important role in realizing precision medicine, most researchers recognize the need to include other types of phenotypic data in addition to medical history and standard clinical assessment.
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