Welcome to the Metabolon Blog!

We post commentary on all things metabolomics – from the latest publications to precision medicine. There are many exciting and growing metabolomics applications, so you never know what will inspire us to start writing. We invite you to subscribe and get each new post directly delivered to your inbox.

The Cancer Metabolism Beachhead Expands with Metabolomics

Dec 10, 2015, 3:25 AM
The beat marches on for cancer metabolism with many compelling results and the entrance of molecules into clinical trials. While cancer metabolism is traditionally viewed as a reprogramming of energy metabolism and metabolic pathways that support cell replication and growth, many investigators are realizing that the metabolic processes that allow a tumor to initiate and thrive are even broader than this.
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Is the Fountain of Youth a Metabolite Away?

Nov 11, 2015, 3:31 AM
The media touts a new stay-young regimen every day, such as caloric restriction (equal to starvation for a food lover like me) or the consumption of red wine (a more palatable undertaking). The truth is, aging is astoundingly complex and is influenced by our diet, environment, genetics and the microbiome within us.
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Using Metabolomics to Reduce Drug Attrition in Pharma R and D

Oct 5, 2015, 3:49 AM
It’s well-known that the time and cost to bring a new pharmaceutical to market are considerable. The average length of time from target ID to a new therapeutic is about 13 years and costs roughly $1.5 billion, embedded within an overall failure rate of 95%. But why?
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Metabolism: an old dog with new tricks

Sep 23, 2015, 3:52 AM
As research showing the intimate connection between metabolism (aka biochemistry) and higher-order cellular function mounts, I am simultaneously excited and puzzled. I get excited by new metabolism research and enthusiastically embrace the importance of it. But, I am often bewildered that, in this gene-centric world, not everyone gets as charged as I do.
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Can Global Metabolonic Profiling be used as a Clinical Tool for Inborn Error of Metabolism Screening?

Sep 11, 2015, 3:56 AM
Global metabolomic profiling is a powerful tool for the discovery of diagnostic biomarkers. Recently, Metabolon has been involved with translational research to extend the application of metabolomics from population studies and biomarker discovery to individual patient testing (N-of-one studies) for the detection of inborn errors of metabolism (IEM).
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What will it take to improve health assessment and realize precision medicine?

Aug 25, 2015, 3:58 AM
When most people think of precision medicine, genomics is top of mind. While genomics will play an undeniably important role in realizing precision medicine, most researchers recognize the need to include other types of phenotypic data in addition to medical history and standard clinical assessment.
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Biology’s “building inspector”

Jul 31, 2015, 4:01 AM
Continuing on the topic of my last post, I wanted to find an analogy that could paint a familiar, vivid picture of how metabolism relates to living systems and genetics and, therefore, why it’s an important research tool. The example a colleague and I came up with was that of a living organism being analogous to a house and the process by which they are constructed.
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Duh, it’s your biochemistry!

Jul 8, 2015, 4:04 AM
A lively discussion happened recently in a staff meeting on the need to raise awareness in the gene and protein world about how metabolism fits into their paradigm and why it’s important. The topic aroused a range of opinions, but on this day, one of my more enthusiastic colleagues proclaimed, “Duh, it’s your biochemistry!”
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