Advancing Research in Skin Biology with Metabolomics
Skin is a metabolic organ that provides a first line of defense against environmental, physical and chemical assaults. The architecture of human skin is complex and each layer possesses a metabolic signature with a unique composition and function. The cumulative impacts of environmental, physical, chemical, and microbiological stresses contribute to biochemical changes that are reflected in skin's metabolome.
Accurately assessing perturbations in skin metabolism can provide a proximal snapshot of phenotype and is key to understanding conditions such as acne, eczema, psoriasis and signs of aging, as well as response to intervention. Here, we present an overview of how metabolomics can be a powerful tool in skin biology research to improve the development process for therapeutics and skin care products.
Finally, we describe indications and applications for these capabilities culminating in highlights of recently published results of an investigation of the effects of sunlight on the metabolomic profile of the skin.
Who Should Attend:
- Dermatology/Skincare Researchers
- Drug/Ingredient Developers
- Cosmetic scientists
- Discovery Biology
- Discovery Chemistry
- Preclinical Development
- Clinical Development
- Biomarker/Target Discovery
- Translational medicine
- Molecular biology/medicine
Tracy Shafizadeh, Ph.D. - Associate Director of Lipomics Services, Metabolon, Inc.