Jump, R L, et al. Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice. PLoS ONE, 2014. 9 (7):e101267.
Antibiotic treatment can disrupt the intestinal microbiota and induce illness through the opportunistic rise of enteric pathogens such as vancomycin-resistant Enterococcus (VRE) or Clostridium difficile. Thus, there is a need to understand and track the specific disruptions that are caused by antibiotic use, colonization by enteric pathogens and the recolonization (recovery) with “good bugs”. To identify biomarkers of this process, investigators used a mouse model. Metabolomic screening of feces revealed a host of biomarkers that marked each stage of this process – antibiotic treatment, colonization with the enteric pathogens, clearance of the enteric pathogens, and recovery of a “normal” microbiota pattern. Hence, the authors were able to derive fecal biomarkers that can be explored in humans with infections such as VRE or Clostridium difficile. Additionally, this same approach could readily be extended to screening of blood.
Metabolon results led to:
- Biomarkers of microbiota changes during antibiotic treatment and subsequent infection