Fontaine, K A, et al. Vaccinia virus requires glutamine but not glucose for efficient replication. J Virol, 2014. 88(8):4366-74.
Vaccinia virus (VACV) is a member of the same family as the virus responsible for smallpox. Continued investigation of the key drivers of viral infection and propagation are key to the development of new therapies for preventing or clearing infection. Thus investigators performed a metabolomic screen on cells infected with VACV revealing a striking change in glutamine metabolism during the course of infection. Indeed, depriving the VACV-infected cells of glutamine or inhibiting the metabolism of glutamine with an inhibitor to glutaminase greatly suppressed virus production. In contrast, glucose deprivation had minimal effects. In summary, this work reveals that VAVC infection results in a unique and exclusive use of a specific carbon source thus providing a potential target for the discovery of novel antiviral therapies based on metabolic inhibitors.source thus providing a potential target for the discovery of novel antiviral therapies based on metabolic inhibitors.
Metabolon results led to:
• Potential new targets for combating vaccinia virus infection