Metabolomics: Gaining Practical Insight into the Biochemical Phenomena of Skin Metabolism
Euro Cosmetics, June 2014
by Tracy Shafizadeh, Ph.D. and Adam Kennedy, Ph.D.
In terms of area, the skin is the largest organ in humans and performs many vital functions as part of the integumentary system. Examples of these include: acting as a permeability barrier, protecting against dehydration, preventing the accumulation of hazardous chemicals from the environment, and serving as a barricade for the immune system.
The architecture of skin is complex and composed of several multicellular layers segregated by distinct barriers. These layers are interconnected through different mechanisms including innervation, blood vessels/circulation, hair follicles and sweat glands. This interconnectivity allows for the exchange of biochemicals between layers, as well as metabolic changes occurring in the more sub-dermal regions. These changes can often be detected in the outer-most layers of skin...