Metabolic individuality underlies genotype and disease association and enhances resolution of genomic studies
Studies seeking to elucidate the genetic basis for disease have been actively pursued in recent times. Genome-wide association studies (GWAS) are a relatively new way for scientists to identify genes involved in human disease. This method searches the genome for small variations that occur more frequently in people with a particular disease than in people without the disease. Understanding the role of genetic predispositions and their interaction with the environmental factors in complex chronic diseases is key to the development of safe and effective therapies, diagnosis and prevention.