Maximizing the production of biofuels and bio-chemicals in culture/fermentation
systems is an empirical process requiring multiple rounds of cause and effect
analysis. Fuel and chemical end-products must be produced at very high volumes
and production processes must be robust, scalable, high yielding and transferable.
Production strains, raw materials and process conditions all impact metabolism and
as a result, affect biomass and output production. Interrogation of the small molecule
biochemicals as they change prior to and compel phenotypic alterations provides
early indications of ensuing phenotypic changes and results in a comprehensive
analysis optimizing cell physiology, nutrient dynamics, synthetic efficiency and
production. Metabolon’s analysis has been successfully applied in a large variety of
expression systems including algae, bacteria, yeast, plant and mammalian cells.

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