Application Notes

The Challenge: Discovery of Disease-Specific Biomarkers Related to Disease Mechanism and Phenotype

With the advent of 'omic technologies and systems biology research, the search for disease-specific biomarkers has flourished. These technologies provide a comprehensive view of the genetic, protein and biochemical nature of disease. The search for disease biomarkers can yield many different types of biomarkers.

The Challenge: Understanding a compound’s on and off target activities with associated toxicities and indications

Utilizing a systems approach to drug discovery has generated a multitude of high affinity compounds for various classes of molecular targets with different degrees of disease state validation. As these compounds are progressed to the clinic, they pass through a number of defined assays to determine compound efficacy as well as possible toxicities. Although these assays give substantial information on certain toxicities and mechanism of action, toxic effects as well as mechanistic understanding can be found further downstream in the pre-clinical to clinical stage.

The Challenge: Optimizing the Production of a Protein Therapeutic

It is widely understood that the production phase of bioprocessing can have a significant impact on the overall profitability of the biopharmaceutical. Organizations must analyze everything from total protein production levels to glycosylation patterns as well as overall quality and stability. It is clear that the final product’s profitability can be dramatically changed by the culture process.