Board of Directors

C. Thomas Caskey, MD, FACP

Mr. Caskey is the director and chief operating officer of the Brown Foundation Institute of Molecular Medicine and the executive vice president of molecular medicine and genetics at the University of Texas Health Sciences Center at Houston. After graduating from the University of South Carolina and Duke University Medical School, Dr. Caskey began a career in medical research that has spanned more than 40 years. During that time, he has held positions with the NIH, NHLBI, and the Baylor College of Medicine. In 1994, he joined Merck Research Laboratories as senior vice president of research and president of the Merck Genome Research Institute. He returned to Houston in 2000 to become founding director and chief executive officer of Cogene Biotech Ventures and Cogene Ventures. Dr. Caskey serves on the boards of several corporations as well as serving as a member of the Science Review Panel for the US Food and Drug Administration. He belongs to numerous scientific organizations and has merited a number of awards for his work and dedication to science.

Jeff Clark

Mr. Clark is managing general partner at The Aurora Funds, a venture capital firm that he co-founded in 1994. Working primarily with Aurora's life sciences portfolio, Jeff leads Aurora's healthcare team to identify new investment opportunities and to support approximately 30 healthcare portfolio companies. Jeff currently serves on the boards of several of Aurora's life science portfolio companies, including Aldagen, Argos, Hyperbranch, and Regado, assisting in the strategic direction of each. Prior to forming Aurora, Jeff spent thirteen years working in development and external affairs for Duke University (including Duke Comprehensive Cancer Center, Duke Medical Center and the School of Engineering). Jeff holds a Bachelor of Science in Mechanical Engineering from Duke University and a MBA from the Fuqua School of Business at Duke University. He maintains strong ties to Duke University, serving on the board of directors of the Duke Comprehensive Cancer Center. Jeff also supports the entrepreneurial efforts of greater RTP community by having served as Chairman of the Board for North Carolina's Council for Entrepreneurial Development (CED) and by co-founding of the North Carolina Initiative for Innovation and Entrepreneurship (NCIIE).

Santo Costa

Mr. Costa has over 40 years in executive and senior operating management positions within the pharmaceutical, health care and life sciences industries and as a legal practitioner. His experience in a major international business service provider and senior counsel and executive management responsibility for a major international pharmaceutical company occurred during periods of explosive growth.

As President and Chief Operating Officer of Quintiles Transnational Corp., Sandy had responsibility for all operating divisions, as well as worldwide business development. Prior to joining Quintiles Transnational Corp, Sandy spent 23 years in the pharmaceutical industry. Most recently, he was Senior Vice President, Administration and General Counsel of Glaxo Inc. where he sat on the company’s Board of Directors and Executive Committee and was deeply involved in managing Glaxo’s growth, which at that time made it the fastest growing pharmaceutical company in the nation.

Sandy is Of Counsel to the law firm Smith, Anderson, Blount, Dorsett, Mitchell & Jernigan. He has sat on the board of directors of numerous companies both public and private and has chaired the boards of several companies.

Sandy is an adjunct professor in the clinical research program at the Campbell University School of Pharmacy. He also sits on The Duke Brain Tumor Advisory Committee, the Duke University Medical Center Board of Visitors, the Duke Cancer Patient Support Program Board of Advisors and the UNC Thurston Arthritis Research Center.

Sandy is the author of the book Humanity at Work: Encouraging Spirit, Achievement & Truth to Flourish in the Workplace (2008).

Sandy received his B.S. in pharmacy and his Juris Doctor degrees from St. John’s University in 1968 and 1971 respectively. In 1998, he was the recipient of the St. John’s University Alumni Outstanding Achievement Medal. He had been licensed to practice pharmacy in New York and Rhode Island and is licensed to practice law in the states of New York, Ohio, and North Carolina.

Guy Fish, MD

Guy Fish, MD has over 25 years of healthcare, life sciences and biotechnology experience. Guy also serves as a Vice President in the Healthcare Practice Group at Fletcher Spaght, the firm’s consulting business. Previously, Guy served as VP of Business Development and International at Collagenesis, a tissue engineering firm. He has also worked as a securities analyst in the medical devices sector for Sanford Bernstein, as a healthcare consultant at The Boston Consulting Group, and was a solo-practice physician. Guy holds an MBA from the Yale School of Management, an MD from the Yale School of Medicine, is board certified in Internal Medicine, and holds an AB in Biochemistry from Harvard College.

Guy is a member of the Board of Directors of Phase Biosciences and BioTrove and serves as an observer of the Boards of Decision Biomarkers, Othera Pharmaceuticals and Proteus Biomedical. He is a Trustee of Beth Israel Deaconess Medical Center, Chairman of the Licensing Board for Dubai Health Care city and former Chairman of the Licensing Committee for the Board of Registration in Medicine for the Commonwealth of Massachusetts.

Rudy Howard

Mr. Howard is currently the Chief Financial Officer for SciQuest, Inc., a publicly traded global software company located in Cary, North Carolina. Before joining SciQuest, he served as CFO for a number of other public and private multi-national companies in the software and life sciences industries, including Pharmaceutical Product Development and Peopleclick. Rudy spent the first half of his career in public accounting, where he became an assurance partner with PricewaterhouseCoopers. He served companies in the pharmaceutical, biotech, high technology and financial services industries. Among his areas of expertise were SEC compliance, including guiding a number of clients through the IPO process, and merger and acquisition consulting. Howard is a Certified Public Accountant and received his Bachelor of Arts in Accounting from North Carolina State University.

Carol A. Marino

Carol Marino is currently Vice President, Syngenta Ventures, responsible for investing in and managing a portfolio of innovative agriculture science companies in the U.S. Her investment focus is to make equity investments in privately held companies which can provide both strategic value as well as financial returns to Syngenta. Carol works closely with Syngenta R&D and business units to ensure strategic alignment so that equity investments made by Syngenta Ventures can become an integral part of Syngenta’s growth strategy.

Prior to joining Syngenta Ventures, Ms. Marino was Vice President of Venture Investments, at Johnson & Johnson Development Corporation, where her venture focus was on equity investments in pharmaceutical and biotech companies at all stages of development. Carol served as a director on the boards of several portfolio companies.

Prior to joining J&J, Carol was the Vice President of Business Development for Clinical Development Capital LLC, a company which provides strategic investment capital to pharmaceutical companies for clinical development. Prior to joining Clinical Development Capital, Carol was a Vice President at Bristol-Myers Squibb Corporation. Throughout her tenure at BMS she held executive positions in Corporate Strategic Planning, Business Development, e-Business Alliances, and Cardiovascular Marketing. As Vice President of the Sanofi Pharma Alliance, Carol managed all aspects of the BMS/Sanofi Joint Venture Alliance. Prior to joining BMS, she held various positions at Merck & Co., Inc., including Strategic Planning, Business Intelligence, Business Analysis and Global Marketing, where she was responsible for bridging the worldwide market needs with R&D programs and priorities. Carol also held sales and marketing positions at Squibb Corporation and Sterling Drug.

Carol holds a Master of Science degree in Organic Chemistry from the University of New Hampshire, and a B.S. in Chemistry from Merrimack College. She is a member of the Scientific Advisory Board of the New York City Investment Fund.

John Oxaal

Mr. Oxaal is a general partner at Sevin Rosen Funds. At SRF, John focuses in areas of imaging, computing, photonics, RF communications, and semiconductors. Before joining SRF in 1999, John co-founded and was CEO of Volumetrics Medical Imaging and was on the founding team of the Digital Signal Processing Division of Analog Devices. John holds several patents in the field of real-time volumetric ultrasound imaging. In addition to continuing as the Chairman of Volumetrics board, John serves on the boards of CADTEL Systems, Ethertronics, Luxtera, Metabolon, and Scintera. Oxaal holds an engineering degree from Duke University and a MBA from the University of Chicago.

John Ryals, Ph.D., President and Chief Executive Officer

Dr. Ryals received a Ph.D. in Molecular Biology from the University of Texas at Dallas. Prior to joining Metabolon, Dr. Ryals was CEO, president and founder of Paradigm Genetics, Inc. (NASDAQ:PDGM). There, he raised over $100 million in equity financing, including an Initial Public Offering in 2000 and a follow on offering in 2001 and closed on R&D partnerships valued at over $200 million. Dr. Ryals has 20 years of experience in the biotechnology industry including senior research positions at Novartis and Ciba-Geigy and currently serves on the Board of North Carolina State University College of Physical and Mathematical Sciences.