Board of Directors

John Ryals, Ph.D., President, Chief Executive Officer & Chairman of the Board

Dr. Ryals has served as Metabolon's president, chief executive officer and chairman of the board of directors since April 2002. Prior to founding Metabolon, he was CEO, president and founder of Paradigm Genetics, Inc., a publicly traded agriculture biotechnology company focused on industrializing the process of gene function discovery. Dr. Ryals has 30 years of experience in the biotechnology industry, including senior research positions at Novartis and Ciba-Geigy, and currently serves on the board of directors of AgBiome, a provider of early-stage R&D for agriculture, and the advisory board of the College of Agriculture and Life Sciences at North Carolina State University. He earned a B.A. in biology and chemistry from the University of North Texas and M.S. and Ph.D. degrees from the University of Texas at Dallas.

Thomas Caskey, M.D., FACP

Dr. Caskey is a professor of molecular genetics at Baylor College of Medicine. Prior to joining Baylor, he was the director and COO of the Brown Foundation Institute of Molecular Medicine and executive vice president of molecular medicine and genetics at the University of Texas Health Sciences Center at Houston. During that time, he held positions with the NIH, NHLBI and the Baylor College of Medicine. Previously, Dr. Caskey was founder and CEO of Cogene Biotech Ventures and Cogene Ventures, which invested in early-stage biotech and life sciences companies that use genome technology for drug discovery, following his tenure at Merck Research Laboratories as senior vice president of research and president of the Merck Genome Research Institute. Dr. Caskey serves on the boards of several corporations, as well as serving as a member of the Science Review Panel for the U.S. Food & Drug Administration. Dr. Caskey is a member of the Institute of Medicine, the National Academy of Sciences, and the Royal Society of Canada. He holds a B.A. from the University of South Carolina and an M.D. from Duke University.

Jeff Clark, M.B.A.

Mr. Clark is a managing general partner at The Aurora Funds, a venture capital firm he co-founded in 1994. Working primarily with Aurora's life sciences portfolio, he leads Aurora's healthcare team to identify new investment opportunities and support approximately 30 healthcare portfolio companies. He currently serves as a director of Cardioxyl Pharmaceuticals,  Hyperbranch Medical Technology, Regado Biosciences and Neotropix, Inc. Prior to forming Aurora, Mr. Clark spent 13 years working in development and external affairs for Duke University (including Duke Comprehensive Cancer Center, Duke Medical Center and the School of Engineering). He serves on the board of overseers of the Duke Comprehensive Cancer Center and board of advisors of the Center for Entrepreneurship and Innovation at the Duke University Fuqua School of Business. Mr. Clark also supports the entrepreneurial efforts of the greater RTP community by having served as chairman of North Carolina's Council for Entrepreneurial Development (CED) and co-founding the North Carolina Initiative for Innovation and Entrepreneurship (NCIIE). He holds a B.S. in mechanical engineering and M.B.A. from Duke University.

Santo Costa, J.D.

Mr. Costa is currently Of Counsel to the law firm Smith, Anderson, Blount, Dorsett, Mitchell & Jernigan, LLP. He was the president and COO of Quintiles Transnational Corp., a clinical research organization, from 1994 to 2001, where he was responsible for all operating divisions and worldwide business development. Prior to joining Quintiles, Mr. Costa spent 23 years in the pharmaceutical industry, including Glaxo, Inc. where he held several positions including senior vice president of administration and general counsel. He also served on the company's board of directors and executive committee. Mr. Costa presently serves as a director of Cytokinetics, Inc. and is the chairman of the board at Alchemia Ltd. He also serves on the Duke Brain Tumor Advisory Committee, the Duke University Medical Center Board of Visitors, the Duke Cancer Patient Support Program Board of Advisors, and the Duke Cancer Institute Board of Overseers. Mr. Costa received both his B.S. in pharmacy and Juris Doctor degrees from St. John’s University. In 1998, he was the recipient of the St. John’s University Alumni Outstanding Achievement Medal. He is licensed to practice law in the states of New York, Ohio and North Carolina.

Guy Fish, M.D., M.B.A.

Dr. Fish has over 25 years of healthcare, life sciences and biotechnology experience. He is a vice president at Fletcher Spaght/Fletcher Spaght Ventures, a hybrid healthcare consulting and venture capital firm. Previously, he served as VP of business development and international at Collagenesis, Inc., a tissue engineering firm. He has also worked as a securities analyst in the medical devices sector for Sanford C. Bernstein & Co., as a healthcare consultant at The Boston Consulting Group, and was a solo-practice, emergency room and intensive care unit physician. Dr. Fish is a director of PhaseBio Pharmaceuticals and serves as an observer of the board at Proteus Digital Health. He is also a trustee of Beth Israel Deaconess Medical Center, chairman of the licensing board for Dubai Healthcare City and former chairman of the licensing committee for the board of registration in medicine for the Commonwealth of Massachusetts. Dr. Fish holds an M.B.A. from the Yale School of Management, an M.D. from the Yale School of Medicine, is board certified in internal medicine, and holds an A.B. in biochemistry from Harvard College.

Rudy Howard, C.P.A.

Mr. Howard is the chief financial officer for SciQuest, Inc., a publicly traded global software company. Before joining SciQuest, he was CFO of MDS Pharma Services and operated his own financial consulting company, where his services included advising on M&A transactions, equity and debt issuances, and other general management matters. He has also served as CFO for a number of other public and private multi-national companies in the software and life sciences industries, including Pharmaceutical Product Development (PPD) and Peopleclick. Mr. Howard spent the first half of his career in public accounting, where he became an assurance partner with PricewaterhouseCoopers. He served companies in the pharmaceutical, biotechnology, high technology and financial services industries. Among his areas of expertise were public company disclosure compliance, including guiding a number of clients through the IPO process, and merger and acquisition consulting. Mr. Howard is a certified public accountant and received his B.A. in accounting from North Carolina State University.

Christopher Kersey, M.D., M.B.A.

Dr. Kersey, a managing member of Camden Partners, focuses on private equity investments in the healthcare and life sciences industries. He serves as a director of Community Education Centers, Inc., Essence Group Holdings, Essia Health, Inc., Implantable Provider Group, Inc., Lumeris Corporation, PatientSafe Solutions, Inc., and Santa Rosa Consulting. Dr. Kersey is also the chairman of the board of Johns Hopkins Medicine International, the global development arm of Johns Hopkins Medicine, and serves on the boards of trustees of Johns Hopkins Medicine and the Johns Hopkins Hospital. He also serves on the board of directors of the Johns Hopkins Hospital Endowment Fund, and he is a member of the Johns Hopkins Medicine compensation and patient safety and quality committees. Dr. Kersey earned his B.A. from Stanford University, his M.B.A. from the Harvard Business School, and his M.D. from the Emory University School of Medicine.

Carol Marino, M.S.

Ms. Marino is currently the managing director of Syngenta Ventures and is responsible for investing in and managing a portfolio of innovative agriculture science companies in the U.S. From 2004 until joining Syngenta Ventures, she was vice president of venture investments at Johnson & Johnson Development Corporation, the venture capital subsidiary of Johnson & Johnson. Prior to joining J&J, Ms. Marino was the vice president of business development for Clinical Development Capital, a company that provides strategic investment capital to pharmaceutical companies for clinical development. Prior to joining Clinical Development Capital, she was a vice president at Bristol-Myers Squibb Corporation. Previous to that role, she held various positions at Merck, including strategic planning, business intelligence, business analysis and global marketing, where she was responsible for bridging the worldwide market needs with R&D programs and priorities. She also held sales and marketing positions at Squibb Corporation and Sterling Drug. Ms. Marino holds an M.S. in organic chemistry from the University of New Hampshire and a B.S. in chemistry from Merrimack College. She is on the board of directors of the North Carolina Biotechnology Center.

John Oxaal, M.B.A.

Mr. Oxaal is a general partner at Sevin Rosen Funds, where he focuses in the areas of imaging, computing, photonics, RF communications, and semiconductors. Before joining Sevin Rosen Funds in 1999, he co-founded and was CEO of Volumetrics Medical Imaging, Inc., a developer of three-dimensional ultrasound technology, and was on the founding team of the digital signal processing division of Analog Devices, Inc. Mr. Oxaal holds several patents in the field of real-time volumetric ultrasound imaging. In addition to continuing as the chairman of Volumetrics' board, he serves on the boards of Airwavz Solutions, Inc., Ethertronics, Inc., Luxtera, Inc., and Scintera Networks, Inc. He holds a B.S. in biomedical engineering from Duke University and an M.B.A. from the University of Chicago. Mr. Oxaal is on the board of visitors at the Duke University Pratt School of Engineering and the Polsky Center for Entrepreneurship at the University of Chicago.



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